And Gloucester's first way fixture, the following weekend, is also a cracker as Nigel Davies' side travel to take on Munster at Thomond Park.
The December double header sees Gloucester square off against Edinburgh at Murrayfield before facing the same opponent at Kingsholm a week later.
Dates, kick off times and television coverage for the first four rounds are confirmed below. As always, details for rounds five and six will not be confirmed until after the conclusion of round four.
Saturday October 12th, Gloucester Rugby vs USA Perpignan, Kingsholm, 6pm, Sky Sports
Saturday October 19th, Munster Rugby vs Gloucester Rugby, 6pm, Thomond Park, Sky Sports
Sunday 8th December, Edinburgh Rugby vs Gloucester Rugby, 1pm, Murrayfield
Sunday 15th December, Gloucester Rugby vs Edinburgh Rugby, 3pm, Kingsholm
10/11/12 January, Gloucester Rugby vs Munster, tbc
17/18/19 January, USA Perpignan vs Gloucester, tbc