May will make his first appearance since injuring an elbow in a preseason friendly in Toulon, while Knight is penciled in to start at tight head.
The back line closely resembles the one that started against Worcester, although Reece Boughton comes in for Jimmy Cowan at scrum half.
The pack is also unchanged with the exception of Nathan Stroud replacing Nathan Taylor at hooker.
Steph Reynolds; Luke Hume, Jonny May, Ryan Mills, Drew Cheshire; Jonny Bentley, Reece Boughton; James Gibbons, Nathan Stroud (Old Centralians), Shaun Knight; Will James, Tom Hicks; Matt Cox, Lewis Ludlow, Gareth Evans
Finlay Sinclair (Cinderford RFC), Joe Smart (Cinderford RFC), Tom Heard, Jonny Hill, Sam Underhill, Billy Burns, Lloyd Evans, tbc