Taking on Quins at the Stoop is tricky enough at the best of times, but losing three men to yellow cards cost Gloucester the game on Saturday, as they shipped 21 points while outnumbered in a 27-19 defeat.
Gloucester Rugby had to overcome first half injuries to Ryan Mills and James Simpson-Daniel, before wearing down a hard working Newcastle Falcons side to clinch their first LV= Cup win of the season by 20 points to 3.
Charlie Sharples may have been a late call up to the Gloucester line up to face Japan, but he made the most of the opportunity, scoring a hat trick as the Cherry and Whites defeated the Cherry Blossoms by 40 points to 5.
Freddie Burns will captain Gloucester for the first time, and 17 year old Ollie Thorley will make his club debut, as the Cherry and Whites travel to Franklin's Gardens on Saturday to open their LV= Cup campaign against Northampton Saints.
Gloucester United rounded off the group stages of the Aviva Premiership A League with a trip to Northampton on Monday evening. The hosts finished off their chances well against a young Gloucester side and came away convincing 49-9 winners.
Flanker Andy Hazell will make his first start of the season as Gloucester look to get back to winning ways in the Aviva Premiership, with London Wasps the visitors to Kingsholm on Saturday (kick off 5pm).