Gloucester have won five from five so far this season and currently sit in third place in the Northern Conference table as the only unbeaten team.
Leicester Tigers currently lead the way with 25 points from their six matches, with Saints in second place on 22 points.
Both sides are already guaranteed to progress to finals day at Allianz Park, though top seeding and a 1st versus 1st 'championship' game spot is up for grabs when the league's pacesetters meet.
Kick off is at 7pm.
Gloucester Rugby U18s:
Will Hayward; Elliott Creed, Charlie Norman, Ollie Thorley, Sam Westcote; Lloyd Evans, Farrell Gwilliam; Will Goodrick-Clarke, Cameron Jones, Jack Spencer; Rory Bartle, Tom Lushington; Harry Wilson, Sam Underhill, Will Safe
Zack Bevan, Joe Mullis, Alex Chalkin, Tyler Jerrum, Toben Ronald, Harry Bassett, Harry Priestner, Clayton Dee