Yann Thomas, Huia Edmonds and Shaun Knight make up a new front row, while Will James comes in to partner James Hudson in the second row.
Behind the scrum, Dan Robson gets the nod at scrum half, and Henry Trinder's release from England duty enables him to line up alongside Ryan Mills in the Gloucester midfield.
It's a big game for the Cherry and Whites as they look to get back to winning ways after last Friday's defeat at the Rec and aim to start moving back up the Aviva Premiership table.
Despite Gloucester's current position in the table, Davies remains upbeat but acutely aware that Wasps come to Kingsholm on a high having defeated Leicester last weekend.
"We're hugely disappointed with where we are, but I'm not worried. I know the quality of this squad and we're going to start winning sooner rather than later.
"We hope to start that on Saturday, although it'll be tough against a Wasps team who are coming off the back of a good win. They'll have a lot of of confidence.
"We've just got to start to realise certain things about our game. Against Bath we gave away 20 penalties, and you're not going to win games like that.
"It takes away a large part of your game and it gives a lot to the opposition. That's the priority. We get that right and things will change."
Rob Cook; James Simpson-Daniel, Henry Trinder, Ryan Mills, Jonny May; Freddie Burns, Dan Robson; Yann Thomas, Huia Edmonds, Shaun Knight; Will James, James Hudson; Tom Savage (capt), Andy Hazell, Sione Kalamafoni
Darren Dawidiuk, James Gibbons, Rupert Harden, Elliott Stooke, Gareth Evans, Jimmy Cowan, Charlie Sharples, Matt Kvesic