Peter Buxton moves to the bench to accommodate Brown's return while Jonny May is also back in the matchday 23 having recovered from his bout of flu.
If Buxton takes the field, it will be his 250th competitive appearance for the club, an impressive feat from a true Gloucester stalwart.
A sell out crowd at Worcester awaits two teams who are in reasonable form with Gloucester unbeaten in their last four games and Worcester having won three of their last four including a valuable Aviva Premiership victory on the road last weekend at London Wasps.
Gloucester won the first encounter between these two sides earlier this season, by 29 points to 8 at Kingsholm, but Sixways has proved to be a tough venue in the past for the Cherry and Whites, a fact not lost upon Head Coach Bryan Redpath.
"Saturday's going to be a massive, massive game. They've got nothing to lose now they've a ten point cushion over Newcastle and it's a derby match.
"We've not gone up there and played particularly well in the past so we have to be hugely focussed as this game is very important to us before we go into the Heineken Cup and LV= Cup for a few weeks.
"We're well aware that they have a very good defensive record. They're very dogged and we're going to have to be very physical to break them down.
"We have to show them the utmost respect because they won't just lie down. It is a derby game and it'll be very tough."
Olly Morgan; Charlie Sharples, Henry Trinder, Mike Tindall, James Simpson-Daniel; Freddie Burns, Rory Lawson; Nick Wood, Scott Lawson, Rupert Harden; Jim Hamilton, Alex Brown; Alasdair Strokosch, Akapusi Qera, Luke Narraway (capt)
Matias Cortese, Dan Murphy, Dario Chistolini, Peter Buxton, Matt Cox, Dave Lewis, Ryan Mills, Jonny May