The number eight will lead a talented side that will also include trialists Apo Satala and Joe Cava.
They will start at seven and six respectively as coach Mark Cornwell also includes winger Mark Foster and prop Alasdair Dickinson.
Freddie Burns, who joined Gloucester in the summer from Bath, gets the nod out inside centre alongside Jonny May, while Dan Norton, Tristan Roberts and Henry Trinder complete the three-quarter line-up.
Up front, Dan Williams moves into the second row and there is also a place for prop Yann Thomas.
GLOUCESTER (v Sale Jets): Dan Norton; Mark Foster, Jonny May, Freddie Burns, Henry Trinder; Tristan Roberts, Dave Lewis; Yann Thomas, Adrian Duncan, Alasdair Dickinson, Andres Pretorious, Dan Williams, Joe Cava, Apo Satala, James Forrester (capt). Reps: Chris Hall, Shaun Knight, Danny Wright, Jed Hooper, Jordi Pasqualin, Charlie Simpson-Daniel, Jack Adams.
Gloucester will continue their A League campaign away to Saracens next Monday. Their first home game will be against Leicester on Monday, September 22 (7.45), before they host Sale at home on Monday, October 6 (7.45). Their last home game will be against Saracens on Monday, January 12. Venues to be confirmed.
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