WILLIE WALKER will start in the pivotal number 10 shirt tomorrow - Gloucester's third different stand-off in three weeks.
Dean Ryan's Guinness Premiership leaders will make the trip to Harlequins with the former Otago Highlander in a new half-back combination alongside scrum-half Rory Lawson.
Walker slots in at stand-off because Ryan Lamb has slight bruising to his shoulder and Chris Paterson, who started against Bristol a fortnight ago, moves to the bench.
There are also returns for winger Lesley Vainikolo and full-back Iain Balshaw as Gloucester look to extend their five point advantage at the top of the table.
Walker will make his 10th appearance of the season in the Premiership tomorrow - his one try coming against Leicester back in September.
"Hopefully, we have learnt some lessons from the last time we had international players available," Ryan said, referring to the defeat against Bristol. "We suffered some basic problems then in terms of preparation and we are keen they don't happen again.
"Players needed to turn up on Monday and show me they wanted to be around and involved. There is no doubt we want to get on a bit of a run and find some form.
"We began that process by thinking our way out of some problems against Newcastle last weekend and we need to build on that tomorrow in what will be a very tough game."
Outside Lawson and Walker, Jack Adams and Anthony Allen continue their midfield partnership, while James Simpson-Daniel, who has 10 tries in 19 games in all competitions, will partner Vainikolo and Balshaw in Gloucester's back three.
Ryan has also made changes up front. Loose-head prop Nick Wood will make his sixth successive start and 17th in total alongside hooker Olivier Azam and tight-head prop Carlos Nieto.
Peter Buxton will move back into the second row alongside Alex Brown, which means Alasdair Strokosch, who started for Scotland against Ireland last Saturday, wears number six, Akapusi Qera comes in for Andy Hazell at openside and Luke Narraway wears the number eight shirt.
Hazell is ruled out with a slight neck injury which means Qera will make his 11th start of the season following his try against Newcastle off the bench last weekend.
"Balance is important and I think this is a side that has a lot of capability," Ryan said. "There is also a great deal of know-how and experience on the bench and at certain times they will also be crucial.
"We need to ensure our preparation is right and if we do that then we are capable of creating a threat against a lot of sides. Harlequins are a real threat and to pick off Saracens last Sunday was a very significant result for them - it will be a tough game."
On the bench, hooker Andy Titterrell will be joined by prop Alasdair Dickinson, lock Marco Bortolami and number eight Gareth Delve.
The three-quarter replacements are scrum-half Gareth Cooper, stand-off Chris Paterson and wing Mark Foster.
GLOUCESTER (v Harlequins, tomorrow, 2.45pm): Iain Balshaw; James Simpson-Daniel, Jack Adams, Anthony Allen, Lesley Vainikolo; Willie Walker, Rory Lawson; Nick Wood, Olivier Azam, Carlos Nieto, Peter Buxton (capt), Alex Brown, Alasdair Strokosch, Akapusi Qera, Luke Narraway. Reps: Andy Titterrell; Alasdair Dickinson, Marco Bortolami, Gareth Delve, Gareth Cooper, Chris Paterson, Mark Foster.
Ben Morgan, Tom Johnson and Henry Thomas spoke to Russ Hargreaves this week as they were about to do some DIY work at Chobham RFC as part of Natwest Rugby Force. On the agenda for discussion were, of course, England's forthcoming games but also the trio's painting prowess.
With ADEY Professional Heating Solutions now unveiled as Gloucester Rugby's new main sponsor from July 2013, managing Director Kelvin Stevens spoke to the club website about the reasons for getting involved with the club.
Gloucester Rugby CEO Stephen Vaughan was delighted to introduce ADEY Professional Heating Solutions as the club's new main sponsor this week. He spoke to the club website about the exciting new partnership.
Although understandably disappointed following the 40-39 defeat at Exeter, Freddie Burns thought that both teams fully contributed to a great spectacle but that a couple of refereeing decisions were key to the outcome.
Gloucester's final game of the season ended in a narrow defeat in a pulsating encounter at the Exeter Chiefs. The Cherry and Whites went down 40-39, as Gareth Steenson's dramatic late penalty meant that the end of Director of Rugby Nigel Davies' first season in charge ended in defeat. Davies spoke to the official website in the Devon sunshine.
Dave Lewis was in a tough situation on Saturday afternoon - playing for Gloucester against the side he will join next season, Exeter Chiefs. At the final whistle though, Lewis was simply disappointed to have lost the game.
Tongan second row Lua Lokotui is looking forward to catching up with some old acquaintances at Sandy Park when Gloucester take on Exeter Chiefs on Saturday afternoon, as he and his team mates hope to finish the season on a high note.
During a break from training ahead of Saturday's Aviva Premiership fixture at Exeter, centre Henry Trinder hopes that Gloucester build on the momentum from the recent win over Saracens, and expressed frustration that he's hitting form as the season end approaches after missing time due to injury.
Gloucester Rugby may have already clinched their Heineken Cup spot for 2013-14, but Director of Rugby Nigel Davies stressed this week that it's important for Gloucester to finish their season on a positive note at Exeter on Saturday.