WILLIE WALKER will start in the pivotal number 10 shirt tomorrow - Gloucester's third different stand-off in three weeks.
Dean Ryan's Guinness Premiership leaders will make the trip to Harlequins with the former Otago Highlander in a new half-back combination alongside scrum-half Rory Lawson.
Walker slots in at stand-off because Ryan Lamb has slight bruising to his shoulder and Chris Paterson, who started against Bristol a fortnight ago, moves to the bench.
There are also returns for winger Lesley Vainikolo and full-back Iain Balshaw as Gloucester look to extend their five point advantage at the top of the table.
Walker will make his 10th appearance of the season in the Premiership tomorrow - his one try coming against Leicester back in September.
"Hopefully, we have learnt some lessons from the last time we had international players available," Ryan said, referring to the defeat against Bristol. "We suffered some basic problems then in terms of preparation and we are keen they don't happen again.
"Players needed to turn up on Monday and show me they wanted to be around and involved. There is no doubt we want to get on a bit of a run and find some form.
"We began that process by thinking our way out of some problems against Newcastle last weekend and we need to build on that tomorrow in what will be a very tough game."
Outside Lawson and Walker, Jack Adams and Anthony Allen continue their midfield partnership, while James Simpson-Daniel, who has 10 tries in 19 games in all competitions, will partner Vainikolo and Balshaw in Gloucester's back three.
Ryan has also made changes up front. Loose-head prop Nick Wood will make his sixth successive start and 17th in total alongside hooker Olivier Azam and tight-head prop Carlos Nieto.
Peter Buxton will move back into the second row alongside Alex Brown, which means Alasdair Strokosch, who started for Scotland against Ireland last Saturday, wears number six, Akapusi Qera comes in for Andy Hazell at openside and Luke Narraway wears the number eight shirt.
Hazell is ruled out with a slight neck injury which means Qera will make his 11th start of the season following his try against Newcastle off the bench last weekend.
"Balance is important and I think this is a side that has a lot of capability," Ryan said. "There is also a great deal of know-how and experience on the bench and at certain times they will also be crucial.
"We need to ensure our preparation is right and if we do that then we are capable of creating a threat against a lot of sides. Harlequins are a real threat and to pick off Saracens last Sunday was a very significant result for them - it will be a tough game."
On the bench, hooker Andy Titterrell will be joined by prop Alasdair Dickinson, lock Marco Bortolami and number eight Gareth Delve.
The three-quarter replacements are scrum-half Gareth Cooper, stand-off Chris Paterson and wing Mark Foster.
GLOUCESTER (v Harlequins, tomorrow, 2.45pm): Iain Balshaw; James Simpson-Daniel, Jack Adams, Anthony Allen, Lesley Vainikolo; Willie Walker, Rory Lawson; Nick Wood, Olivier Azam, Carlos Nieto, Peter Buxton (capt), Alex Brown, Alasdair Strokosch, Akapusi Qera, Luke Narraway. Reps: Andy Titterrell; Alasdair Dickinson, Marco Bortolami, Gareth Delve, Gareth Cooper, Chris Paterson, Mark Foster.
Previewing Friday evening's local derby at Bristol, Interim Head Coach Jonny Bell told the local media that Gloucester's preparations have gone well and that the whole squad is united in trying to finish the season on a high.
Speaking to GRTV this week, Acting Head Coach Jonny Bell spoke of his pleasure in the efforts and intensity in training from the squad after a tricky few weeks. The team were preparing for big games with Bristol and Cardiff in coming weeks.
Willi Heinz was understandably and visibly disappointed when he spoke to GRTV after the 27-30 home defeat to Harlequins, apologising to the home support as the game slipped away after seemingly having the game under control.
Speaking to the local media this week, Scottish centre Matt Scott spoke of the squad's determination to put in a big home performance against Harlequins, with vital points up for grabs in the hunt for a Top Six spot this Saturday (KO 3pm)
Looking ahead to Saturday's Aviva Premiership fixture at home to Harlequins (kick off 3pm), Head Coach Laurie Fisher told the local media that Gloucester will need to be on top of their game in a match which has big implications in terms of top six ambitions.
A big few days for the Gloucester-Hartpury Women side. First came the news that the team will compete in Women's Super Rugby next season, and on Saturday the team will play Worcester Ladies IIs at Kingsholm. Centre Hannah Jones and wing Michelle Ruddock spoke to GRTV this week to reflect on events.
In the aftermath of the Aviva Premiership victory over Bristol, Interim Head Coach Jonny Bell was able to look forward to this weekend's European Rugby Challenge Cup quarter-final against Cardiff Blues (Kingsholm, kick off 8:05pm).
Missing so many starters, and up against a team fighting for their Premiership existence, Gloucester did what had to be done at Ashton Gate on Friday evening battling their way to a 32-14 Aviva Premiership win over Bristol Rugby.