GLOUCESTER will welcome back a raft of internationals on Sunday when they make the trip to the Memorial Stadium to face Bristol (3pm).
England trio Lesley Vainikolo, Iain Balshaw and Luke Narraway will be joined by Scotland's Chris Paterson, Italy's Marco Bortolami and Carlos Nieto and Gareth Delve of Wales in a much-changed line-up named by head coach Dean Ryan.
The changes will see a significant shift in Ryan's starting line-up following their 20-13 defeat to Leicester last weekend.
Paterson will return at stand-off to replace Willie Walker and will make his fourth start of the season at number 10. Ryan Lamb is ruled out with a shoulder injury. He will partner Gareth Cooper at half-back, who makes his first Premiership start since Gloucester's 20-13 victory away to Newcastle before Christmas.
The centre partnership of Anthony Allen and Jack Adams remains the same as the one that faced Leicester, while James Simpson-Daniel will be partnered by Vainikolo - who will make his first start since the victory over Ulster in January - and full-back Iain Balshaw, who comes in for James Bailey in the back three.
Up front, there are also considerable changes. Nick Wood is the only remaining member of the front row that start against Leicester as Carlos Nieto returns at tight-head and is joined at hooker by Jeremy Paul, who will make his first Guinness Premiership start.
At lock, Marco Bortolami returns from the fractured eye socket sustained against Ulster and will partner Will James. Peter Buxton, who has featured in 16 games this season, moves to the bench.
Narraway, who has won his first two England caps against Wales and Italy, comes in at number six in place of Alasdair Strokosch, Andy Hazell retains the number seven shirt and Gareth Delve returns at number eight.
"Although we lost against Leicester last weekend we saw a clear image of what we want to be as a side," Ryan said. "We can take a lot of positives from that performance and obviously this week the group has returned to something like full strength so we want to see a continuation of that process.
"Losing a game like last weekend is not a huge concern simply because of what we got out of it and how we can progress it long-term. We are beginning a period of some crucial matches and that continues on Sunday against Bristol.
"We know they are an outstanding side at the nuts and bolts of the game and when that functions they are capable of taking a team apart - you only have to look at what happened to Stade Francais in the Heineken Cup to appreciate their threat.
"It is our job to get our game right and if that unfolds in the right way I am confident we have the ability to match anybody. These games are special - they are special for the supporters and special for the players and it is something we are looking forward to."
On the bench, scrum-half Rory Lawson will be joined by utility back Willie Walker and wing Mark Foster.
The forwards are made up of hooker Andy Titterrell as Olivier Azam is given a rest, prop Alasdair Dickinson, Buxton and Strokosch.
GLOUCESTER (v Bristol, Sunday, 3pm): Iain Balshaw; James Simpson-Daniel, Jack Adams, Anthony Allen, Lesley Vainikolo; Chris Paterson, Gareth Cooper; Nick Wood, Jeremy Paul, Carlos Nieto, Marco Bortolami (capt), Will James, Luke Narraway, Andy Hazell, Gareth Delve. Reps: Andy Titterrell, Alasdair Dickinson, Peter Buxton, Alasdair Strokosch, Rory Lawson, Willie Walker, Mark Foster.
Previewing Friday evening's local derby at Bristol, Interim Head Coach Jonny Bell told the local media that Gloucester's preparations have gone well and that the whole squad is united in trying to finish the season on a high.
Speaking to GRTV this week, Acting Head Coach Jonny Bell spoke of his pleasure in the efforts and intensity in training from the squad after a tricky few weeks. The team were preparing for big games with Bristol and Cardiff in coming weeks.
Willi Heinz was understandably and visibly disappointed when he spoke to GRTV after the 27-30 home defeat to Harlequins, apologising to the home support as the game slipped away after seemingly having the game under control.
Speaking to the local media this week, Scottish centre Matt Scott spoke of the squad's determination to put in a big home performance against Harlequins, with vital points up for grabs in the hunt for a Top Six spot this Saturday (KO 3pm)
Looking ahead to Saturday's Aviva Premiership fixture at home to Harlequins (kick off 3pm), Head Coach Laurie Fisher told the local media that Gloucester will need to be on top of their game in a match which has big implications in terms of top six ambitions.
A big few days for the Gloucester-Hartpury Women side. First came the news that the team will compete in Women's Super Rugby next season, and on Saturday the team will play Worcester Ladies IIs at Kingsholm. Centre Hannah Jones and wing Michelle Ruddock spoke to GRTV this week to reflect on events.
Missing so many starters, and up against a team fighting for their Premiership existence, Gloucester did what had to be done at Ashton Gate on Friday evening battling their way to a 32-14 Aviva Premiership win over Bristol Rugby.