Akapusi Qera will return on the openside flank in place of Andy Hazell, Alasdair Strokosch replaces Peter Buxton at number six and Iain Balshaw returns to the wing in place of Chris Paterson - none of the trio featured last weekend.
Both Olly Morgan and Anthony Allen are out through injury - Morgan has a hamstring strain and Allen a shoulder injury following Gloucester's defeat against Munster. Willie Walker will replace Morgan at full-back and Mike Tindall comes in for Allen in the centre.
Both Qera and Balshaw have recovered from head injuries sustained against Worcester a fortnight ago to take their places for the Guinness Premiership leaders.
The rest of Ryan's line-up remains the same as the one that lost to Munster 16-3 in the Heineken Cup quarter-final last weekend.
"We did not have four or five weeks of playing well going into the Munster game, but given the disruption, we played really well. The key now is to take that forward," Ryan said.
"The side we want to be was there against Munster in a lot of ways but we need to replicate that in the rest of our games to be competitive towards the end of the Premiership season.
"We have to learn from last weekend and learn from last year's experiences. If we can do both those things, and maximise our opportunities, we've got a chance of being really competitive in the knockout stages of the competition.
"I believe very strongly we are getting better and maturing. Nobody wanted to experience last weekend but we have to get better from it and understand and appreciate the lessons, take that forward into tomorrow and be competitive.
"Saracens are in some great form - their victory over the Ospreys was tremendous - and they have just come off the back of scoring 10 tries against Leeds. They will be confident but it is our job to go out and produce a performance."
Gloucester's front row of Nick Wood, Andy Titterrell and Carlos Nieto will pack down for the third successive match. It will be Wood's 11th successive start in all competitions and it will be Titterrell's fifth in a row.
At lock, Marco Bortolami will skipper the side alongside Alex Brown. Strokosch comes in at six, while Qera will make his 18th appearances in all competitions this season and he has four tries to his name. Completing the back row is number eight Luke Narraway.
Scrum-half Rory Lawson, a try scorer in Gloucester's 17-14 defeat against Worcester, will partner Ryan Lamb at half-back and it will be Lamb's third game back from shoulder damage.
In the centre, Mike Tindall will make his first start in Gloucester colours since their 18-17 win over London Wasps in January after returning from liver damage last weekend following his injury on England duty in the Six Nations Championship.
He will partner James Simpson-Daniel in midfield. Simpson-Daniel is Gloucester's leading try scorer this season with 11 in 23 games and it will be his third successive game in the number 13 shirt.
There are also changes in the back three. Balshaw comes in on the wing in place of Chris Paterson, who moves to the bench. Walker will make his first start at full-back since Gloucester's 28-20 win over Newcastle in February. Lesley Vainikolo, a try-scorer against Worcester, will complete the back three.
On the bench, there are returns for hooker Olivier Azam and prop Jack Forster. Number eight Gareth Delve and lock Will James complete the forward options.
Paterson, scrum-half Gareth Cooper and centre Jack Adams are the three-quarter replacements. Adams has not featured since breaking his nose against Irish at the start of March.
GLOUCESTER (v Saracens, tomorrow, 12.35pm): Willie Walker; Iain Balshaw, James Simpson-Daniel, Mike Tindall, Lesley Vainikolo; Ryan Lamb, Rory Lawson; Nick Wood, Andy Titterrell, Carlos Nieto, Marco Bortolami (capt), Alex Brown, Alasdair Strokosch, Akapusi Qera, Luke Narraway. Reps: Olivier Azam, Jack Forster, Gareth Delve, Will James, Gareth Cooper, Chris Paterson, Jack Adams.
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