England's tries were scored by Christian Wade (Wasps), Marcus Watson (London Irish), Joe Marler (Harlequins) in addition to the one by May.
Freddie Burns contributed three conversions and a penalty before the game was cut short due to floodlight failure.
The match celebrated the life of England Students hooker Dan James, who died in September 2008, 18 months after he was paralysed in a training ground accident. James played in two BUSA Championship-winning Loughborough teams, scoring two tries in the 2006 final against Bath.
For England last night's contest was the final warm-up act before flying out to Argentina where they face the host nation, Ireland and France in the pool stages in Rosario.
Last night, there was no chance of a slip-up as they seized control with the sharpness of their build-up play and finishing.
Wade - on duty with England Sevens at Twickenham this weekend - powered through a tackle in the left-hand corner early on and fellow wing Watson added the second from 20 metres out before Harlequins prop Marler drove over from close range.
Burns converted all three and added a penalty for a 24-6 half-time lead with Matt Keville replied with two penalties for the students.
The lead would have been healthier if Watson and skipper Jacob Rowan hadn't both lost the ball over the line either side of the interval and Loughborough responded with a good spell of pressure before lock Jon Aston forced his way over for their only try.
England dominated the rest of the third quarter with May touching down to extend the lead before referee Greg Garner called a halt when the lights faded 17 minutes from time.
Tom Catterick (Newcastle Falcons); Christian Wade (London Wasps), Jonny May (Gloucester Rugby), Andrew Forsyth (Leicester Tigers), Marcus Watson (London Irish); Freddie Burns (Gloucester Rugby), Charlie Davies (Stade Francais); Joe Marler (Harlequins), Arthur Ellis (London Wasps), Shaun Knight (Gloucester Rugby), George Kruis (Saracens), Charlie Matthews (Harlequins), Will Welch (Newcastle Falcons), Jacob Rowan (Leeds Carnegie, Captain), Jackson Wray (Saracens).
Alex Waller (Northampton Saints), Jamie George (Saracens), Calum Green Leicester Tigers), Alex Gray (Newcastle Falcons), Sam Harrison (Leicester Tigers), Tom Casson (Harlequins), Rory Clegg (Harlequins), Tom Homer (London Irish), Sam Smith (Harlequins).
Geraint Walsh; Kristian Cook, James Golledge, Joe Munro, Nathan Lambden; Matt Keville, Will Chudley; Jeremy Cunnew, Neil Sweeney, Matt Berry, Jon Aston, Will Warden (captain), Anders Nilsson, Dave Hughes, Phil Burgess.
Jack Steadman, Camilo Parilli, Tom Cobb, James Taylor, Jamie Cullen, Fred Silcock, Henry Pyrgos, George Drake, Ross Turner, Ashley Smith, Oscar Ward.