Ireland U20 beat England in the RBS U20 6 Nations, so there will be no shortage of motivation for Mark Mapletoft's team.
Mapletoft has made ten changes in all. Jonny May (Gloucester), hat-trick hero of the 48-22 win against Los Pumitas drops to the bench, replaced by Andrew Forsyth of Leicester Tigers. His Gloucester team-mate Freddie Burns also moves to the bench with Rory Clegg of Harlequins taking his place.
Stade Francais scrum half Charlie Davies makes his first start for the Under 20s, as do Bristol's Mako Vunipola at prop and lock George Kruis of Saracens. Hooker Rob Buchanan (Harlequins) will be hoping to get a game from the bench to get his first taste of action in the tournament.
Head coach Mark Mapletoft has had to balance the needs of facing a dangerous Irish side with the fact that there is so much game-time still to come in a tournament where every team plays five games.
"We know this is a tough group, but we want to win each game, so we've picked a side to try and do that. At the same time we can't expect 80 minutes from all our players every three days.
"We need to make sure we give ourselves the chance to beat France as well. It's a difficult and challenging group but we are doing what we can to keep things fresh.
"It was a great atmosphere against Argentina, I played many years down at Gloucester but at times on Saturday Newell's Old Boys made Kingsholm seem like an old ladies tea party. The initial wave of sound was ferocious so it took us a while to get into the game but I think mentally the guys will be much better prepared this time around."
England U20 v Ireland U20,
Stadio El Coloso del Parque,
Rosario, Kick off 14.10 local, 18.10 GMT
15 Tom Homer (London Irish); 14 Christian Wade (London Wasps), 13 Andrew Forsyth (Leicester Tigers), 12 Tom Casson (Harlequins), 11 Sam Smith (Harlequins); 10 Rory Clegg (Harlequins), 9 Charlie Davies (Stade Francais); 1 Lee Imiolek (Sale Sharks), 2 Jamie George (Saracens), 3 Mako Vunipola (Bristol); 4 George Kruis (Saracens), 5 Charlie Matthews (Harlequins); 6 Jamie Gibson (London Irish), 7 Jacob Rowan (Leeds Carnegie, captain), 8 Alex Gray (Newcastle Falcons)
16 Rob Buchanan (Harlequins), 17 Joe Marler (Harlequins), 18 Calum Green (Leicester Tigers), 19 Jackson Wray (Saracens), 20 Sam Harrison (Leicester Tigers), 21 Freddie Burns (Gloucester), 22 Jonny May (Gloucester)