Freddie Burns is set to play for the first time since recent calf surgery as he has been named to start at fly half in the A League against Saracens at Kingsholm on Monday evening.
Also set to feature on Monday evening is Fijian international winger Semi Tadulala whilst there is plenty of first team experience in the pack particularly with a front row of Pierre Capdevielle, Darren Dawidiuk and Paul Doran-Jones and in a back row including Peter Buxton and Apo Satala.
Burns has made nine appearances in total this season but last featured at Harlequins in the Guinness Premiership at the end of November before undergoing surgery to alleviate problems with cramp.
The pitch at Kingsholm was covered as soon as the Guinness Premiership fixture against Worcester Warriors on Saturday was completed.
However, with bitterly cold conditions predicted for Gloucester over the next 24 hours, should there be any doubts over the fixture taking place then the club website will be updated first.
Stefan Hawley; David Akinluyi, Mark Foster, Jack Hayes, Semi Tadulala; Freddie Burns, Charlie Simpson-Daniel; Pierre Capdevielle, Darren Dawiduik, Paul Doran-Jones; Danny Wright, Dan Williams; Peter Buxton, Richard Jenkins, Apo Satala
Ben Phillips, Yann Thomas, Shaun Knight, James Kirubirru, Marcus Brown, Danny Pointon, Mike Wilcox, Reuben Haile
A handful of the Gloucester Rugby Mo-Bros visited Pride Hair Salon in Gloucester on Wednesday afternoon to have the final touches applied to their Movember efforts, and the team captain Jacob Rowan spoke to GRTV ahead of the final few days of the month.
Northampton away was the first Gloucester game under David Humphreys last season, but the Director of Rugby told the local media that the Cherry and Whites are a different proposition compared to 12 months ago and are looking forward to the challenge.
Having skippered Gloucester against the Barbarians last week, Nick Wood once again wore the captain's armband on Monday evening as Gloucester United kicked off their Aviva Premiership A League campaign with a bonus point win at Leicester.
Gloucester recorded a 32-20 win over La Rochelle on Thursday evening, and second row Jeremy Thrush was thrilled to pick up the victory on his first taste of a trip to France and the hostile atmosphere.
Gloucester were forced to battle for their 33-20 victory in La Rochelle on Thursday evening, something that centre Bill Meakes said that he and the squad were well prepared for as well as thanking the travelling support for the part they played.
Gloucester got off to a winning start in the European Rugby Challenge Cup last weekend, but Head Coach Laurie Fisher is expecting a much tougher challenge when the Cherry and Whites travel to La Rochelle for Thursday night's Round Two encounter.
Dan Thomas was a try scorer in the 14-62 defeat at the hands of the Barbarians on Tuesday evening, but told GRTV after the game that he'd really enjoyed taking on the Barbarians and locking horns with Ardie Savea at the breakdown.
After missing out on Gloucester's two recent European fixtures, Jonny May is back on the left wing for Friday evening's Aviva Premiership fixture at Northampton, while Mariano Galarza is named in the matchday squad for the first time this season.