Freddie Burns is set to play for the first time since recent calf surgery as he has been named to start at fly half in the A League against Saracens at Kingsholm on Monday evening.
Also set to feature on Monday evening is Fijian international winger Semi Tadulala whilst there is plenty of first team experience in the pack particularly with a front row of Pierre Capdevielle, Darren Dawidiuk and Paul Doran-Jones and in a back row including Peter Buxton and Apo Satala.
Burns has made nine appearances in total this season but last featured at Harlequins in the Guinness Premiership at the end of November before undergoing surgery to alleviate problems with cramp.
The pitch at Kingsholm was covered as soon as the Guinness Premiership fixture against Worcester Warriors on Saturday was completed.
However, with bitterly cold conditions predicted for Gloucester over the next 24 hours, should there be any doubts over the fixture taking place then the club website will be updated first.
Stefan Hawley; David Akinluyi, Mark Foster, Jack Hayes, Semi Tadulala; Freddie Burns, Charlie Simpson-Daniel; Pierre Capdevielle, Darren Dawiduik, Paul Doran-Jones; Danny Wright, Dan Williams; Peter Buxton, Richard Jenkins, Apo Satala
Ben Phillips, Yann Thomas, Shaun Knight, James Kirubirru, Marcus Brown, Danny Pointon, Mike Wilcox, Reuben Haile
Gloucester travel to Oyonnax for the second round of the European Rugby Challenge Cup on Saturday evening, and Director of Rugby David Humphreys is expecting a big test from the French side, feeling that their league position doesn't reflect their recent performances.
Speaking exclusively to Gloucester Rugby TV, Matt Kvesic explained that his decision to extend his contract at Kingsholm was a simple one and that he was hugely excited for the future in Cherry and White.
Speaking after the 55-0 win over CA Brive, Jonny May told GRTV that he's delighted that the team's hard work is starting to pay dividends but was equally happy for his friend and team mate, Charlie Sharples, on what was a big night for his fellow winger.
Speaking to the local media this week, David Humphreys insisted that Gloucester are looking forward to kicking off the new European Rugby Challenge Cup against Brive on Thursday evening, although an unfamiliar opponent and a five day turnaround will pose a challenge.