Freddie Burns is set to play for the first time since recent calf surgery as he has been named to start at fly half in the A League against Saracens at Kingsholm on Monday evening.
Also set to feature on Monday evening is Fijian international winger Semi Tadulala whilst there is plenty of first team experience in the pack particularly with a front row of Pierre Capdevielle, Darren Dawidiuk and Paul Doran-Jones and in a back row including Peter Buxton and Apo Satala.
Burns has made nine appearances in total this season but last featured at Harlequins in the Guinness Premiership at the end of November before undergoing surgery to alleviate problems with cramp.
The pitch at Kingsholm was covered as soon as the Guinness Premiership fixture against Worcester Warriors on Saturday was completed.
However, with bitterly cold conditions predicted for Gloucester over the next 24 hours, should there be any doubts over the fixture taking place then the club website will be updated first.
Stefan Hawley; David Akinluyi, Mark Foster, Jack Hayes, Semi Tadulala; Freddie Burns, Charlie Simpson-Daniel; Pierre Capdevielle, Darren Dawiduik, Paul Doran-Jones; Danny Wright, Dan Williams; Peter Buxton, Richard Jenkins, Apo Satala
Ben Phillips, Yann Thomas, Shaun Knight, James Kirubirru, Marcus Brown, Danny Pointon, Mike Wilcox, Reuben Haile
Willi Heinz was understandably and visibly disappointed when he spoke to GRTV after the 27-30 home defeat to Harlequins, apologising to the home support as the game slipped away after seemingly having the game under control.
Speaking to the local media this week, Scottish centre Matt Scott spoke of the squad's determination to put in a big home performance against Harlequins, with vital points up for grabs in the hunt for a Top Six spot this Saturday (KO 3pm)
Looking ahead to Saturday's Aviva Premiership fixture at home to Harlequins (kick off 3pm), Head Coach Laurie Fisher told the local media that Gloucester will need to be on top of their game in a match which has big implications in terms of top six ambitions.
A big few days for the Gloucester-Hartpury Women side. First came the news that the team will compete in Women's Super Rugby next season, and on Saturday the team will play Worcester Ladies IIs at Kingsholm. Centre Hannah Jones and wing Michelle Ruddock spoke to GRTV this week to reflect on events.
Speaking to the local media after the 35-22 loss at Wasps, lock Tom Savage spoke of his disappointment at the result, with Gloucester left to rue a number of missed opportunities against a clinical home side.
Speaking to the local media this week, back row flanker Jacob Rowan said that he is excited for the challenge at the Ricoh Arena this Sunday, and added that the players know the responsibility is theirs to deliver against the league leaders.
Speaking after his return from England duty, Gloucester winger Jonny May reflected on England winning the Six Nations Championship, if not the Grand Slam, and what he needs to focus on to get back into the starting line-up.
Ross Moriarty started for Wales at the Stade de France on Saturday while Matt Scott was a replacement for Scotland. It was Scott who finished the day the happier, a try-scorer in a 29-0 victory over Italy.
Ireland U20s came within inches of spoiling the party at Donnybrook on Friday evening, but Henry Walker's first half try proved to be the difference as England U20s hung on to win 14-10 and clinch their first Grand Slam for five years.
It's the final round of Six Nations action this weekend, and it's not just Eddie Jones' senior England side going for a Grand Slam. So too, are the England U20s with three Gloucester players set to start in the big game against Ireland.