GLOUCESTER hooker Mefin Davies has been diagnosed with a damaged vein in his left calf following the injury he picked up against Saracens almost a fortnight ago.
The Welsh international hooker will be monitored over the next fortnight by Gloucester's medical team but there is no indication yet on a potential comeback date.
Davies has featured in six of Gloucester's seven Guinness Premiership games so far this season.
Head coach Dean Ryan said: "We recognise Mefin is an integral part of our squad but we have made it clear this season we are not prepared to rush players back from injury and he will have all the support required to recover fully.
"The timing is very unfortunate for Mefin but it will provide opportunities for other players within our squad to stake their claim for a starting spot."
Speaking with the local media before the Gloucester team set off on the long trip north to Newcastle, Director of Rugby David Humphreys discussed his team selection and stated that Friday night's meeting will be a challenging one.
Speaking to the local media on Thursday, Matt Kvesic was looking forward to the trip to Newcastle Falcons, and the captain is looking to lead from the front with plenty for the Cherry and Whites to work on.
Gloucester saw a 12-0 lead overturned by Harlequins on Friday night as the visitors ran out 22-15 winners. After the game, Director of Rugby David Humphreys spoke about missed opportunities on the night.
Speaking to the local media on Thursday, James Hudson explained his excitement for tonight's game with Harlequins and that he is backing the Cherry and White squad to impress during the next set of Aviva Premiership games.
Despite a dream start at Kingston Park, scoring a try after just 26 seconds, Gloucester couldn't capitalise against a dogged Newcastle Falcons side. Too many penalties were conceded and too many errors made as the Falcons prevailed 20-10.
There are three changes to Gloucester Rugby's starting line-up for Friday evening's Aviva Premiership fixture away at Newcastle Falcons. Steve McColl will make his first Premiership start for the club.