And the Kingsholm winger cannot wait to get back into the action following yet more injury heartache on England's summer tour to Australia, where he was ruled out of action with a badly bruised left leg.
But he will return to action at Stradey Park, desperate to get some rugby in his legs as time ticks down to the start of the Guinness Premiership season.
Head coach Dean Ryan has yet to finalise his line-up but it is expected that Simpson-Daniel will be joined in the starting XV by centre Anthony Allen, locks Jonathan Pendlebury and Adam Eustace, props Patrice Collazo and Christian Califano, Willie Walker and Ludovic Mercier.
"Some of the guys have been back in pre-season training for 10 weeks and last week could not wait to get back onto the paddock and get a bit of a puff on - I know exactly how they feel," Simpson-Daniel said.
"It will be great to get back out there and get some miles in the tank. All the boys look ultra-fit, are raring to go and want to progress from the game last week.
"There is plenty of time for us to find form and the right combinations - it is a very long season - but we obviously want to take more from this match than the first one and continue to build on the foundations which to me look very, very strong.
"My leg feels fine and I just cannot wait to get that Gloucester shirt on again."
It is expected that Gloucester's line-up will again see new combinations and faces as Ryan moulds his squad together. Ryan Lamb will not be considered for selection because of an ankle injury.
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