Olly Morgan returns to the full-back position in place of Iain Balshaw and both half-backs - Rory Lawson and Ryan Lamb - start in place of Pete Richards and Willie Walker.
Up front, Christian Califano switches across to loosehead as Carlos Nieto returns at tighthead, hooker Mefin Davies makes his first start since the game against Saracens in October while James Forrester comes in at number eight in place of Luke Narraway after successfully returning from a knee operation.
There is also a return on the bench for flanker Jake Boer as Gloucester aim to bounce back from two successive Premiership defeats.
GLOUCESTER: Olly Morgan; James Simpson-Daniel, Mike Tindall, Anthony Allen, Mark Foster; Ryan Lamb, Rory Lawson, Christian Califano, Mefin Davies, Carlos Nieto, Marco Bortolami (capt), Alex Brown, Peter Buxton, Andy Hazell, James Forrester. Reps: Olivier Azam, Patrice Collazo, Adam Eustace, Jake Boer, Peter Richards, Iain Balshaw, Willie Walker.
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