Italian national captain Marco Bortolami returns to the second row in place of Adam Eustace in the only change to the 22.
Bortolami was shifted to the bench for Friday's game but returns to skipper the side alongside Alex Brown in the second row.
It means that both James Forrester and Mefin Davies retain their places on the bench for the trip to High Wycombe and Ryan told www.gloucesterrugby.co.uk "If we can get anything from an away game against Wasps it would be a good start to the Christmas period for us.
"But we appreciate this is a massive test for us. They will be looking to regroup from their defeat on Friday and will be pretty stoked up in a tough environment.
"Wasps' home record speaks for itself but we have a group of players desperate for an opportunity to impress against one of the best teams around and we are thoroughly looking forward to it."
In the front row, Patrice Collazo will start at loosehead and will be joined by hooker Olivier Azam and tighthead Christian Califano.
Peter Buxton, breakaway Andy Hazell and Luke Narraway complete the pack in the back row.
The backs also remain intact which gives Peter Richards and Willie Walker another opportunity at half-back and they will have Mike Tindall and Anthony Allen outside them in the centre.
James Simpson-Daniel, Mark Foster and Iain Balshaw form the back three.
"We wanted to play on Friday but are now solely focused on Wasps," Ryan added. "As a group we have plenty we want to achieve and that means we have to test ourselves against one of the best teams."
GLOUCESTER (v Wasps, Boxing Day): Iain Balshaw; James Simpson-Daniel, Anthony Allen, Mike Tindall, Mark Foster; Willie Walker, Peter Richards; Patrice Collazo, Olivier Azam, Christian Califano, Marco Bortolami (capt), Alex Brown, Peter Buxton, Andy Hazell, Luke Narraway. Reps: Mefin Davies, Carlos Nieto, Adam Eustace, James Forrester, Rory Lawson, Ryan Lamb, Olly Morgan.
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