The Kingsholm club can return to the top of the Premiership with victory over the Falcons and Ryan has virtually a full strength squad to select from - and welcomes back both number eight James Forrester and hooker Mefin Davies and both will sit on the bench.
Forrester has been out of action since the end of October following surgery on a knee problem, while Davies suffered a calf injury against Saracens in November.
There are two changes to the front row, where Patrice Collazo will return from a one-game suspension at loose-head and Christian Califano comes in for Carlos Nieto, who drops to the bench.
In the second row, Adam Eustace comes in for Marco Bortolami, who also moves to the bench and he will partner Alex Brown.
The rest of the pack remains unchanged which means Peter Buxton is at number six, Andy Hazell at openside and Luke Narraway, who scored last Sunday, at number eight.
In the backs the only changes are at half-back. Pete Richards will start at scrum-half and Willie Walker will get a run at stand-off in place of Ryan Lamb.
"We have a picked a team suitable for this game and the threat Newcastle pose to us," Ryan told www.gloucesterrugby.co.uk
"We have got a very strong squad to select from at a very important stage of the season and that is very pleasing. To have guys like James Forrester and Mefin Davies available after injury is pleasing and we also have the option to look and new combinations.
"Newcastle have already beaten Sale away and leaders Bristol so we are expecting a very tough examination on the back of two very difficult European games."
Anthony Allen and Mike Tindall form the centre combination, while James Simpson-Daniel, Mark Foster and Iain Balshaw complete the back three.
GLOUCESTER (v Newcastle, tomorrow, 7.30pm): Iain Balshaw; James Simpson-Daniel, Mike Tindall, Anthony Allen, Mark Foster; Willie Walker, Pete Richards; Patrice Collazo, Olivier Azam, Christian Califano, Adam Eustace, Alex Brown, Peter Buxton (capt), Andy Hazell, Luke Narraway. Reps: Mefin Davies, Carlos Nieto, Marco Bortolami, James Forrester, Rory Lawson, Ryan Lamb, Olly Morgan.
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