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Gloucester will include Henry Paul, Rudi Keil, James Bailey, Ryan Lamb and Brad Davies in an exciting backline, while James Parkes, Jack Forster, Quinton Davids and Mark Cornwell, Will Matthews and James Merriman all get the chance up front.
Both Cornwell and Davids featured in Saturday's European Challenge Cup victory over Bucuresti and they will be asked to front up against a Tigers pack that includes a number of high profile players.
Leo Cullen and James Hamilton line-up in the second row, while Tom Croft, Will Skinner and Henry Tuilagi feature in a heavy-duty back row.
Scott Bemand will skipper the side from scrum-half and the game is free to season ticket holders, is £5 to non-season ticket holders and £1 for kids.
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