Forrester has been examined by both Gloucester Rugby's and England's medical teams and is expected to be out of action for up to six weeks after picking up the injury during Gloucester's 37-20 Heineken Cup defeat to Leinster.
"James has been one of our stand-out performers so far this season and is capable of becoming an international-quality forward," said his club coach Dean Ryan. "This injury is obviously devastating news for him, Gloucester and England.
"But everyone will offer him all the support he needs to make a full recovery - he is a very determined individual and we obviously hope to see him back in action as soon as possible."
England Head Coach Andy Robinson OBE said: "We wish James a speedy and complete recovery. It is a blow for Gloucester and England because he was very much in contention for this series but the important thing for him now is that he gets the best treatment and rehabilitation."
Forrester, the Guinness Premiership player of the month for September, has made six appearances in all competitions and has scored four tries.
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