London Irish have made five changes to the starting line-up for Gloucester's visit to the Madejski Stadium on Saturday 26 March (kick off 5pm).
The changes come on the back of the defeat to Leicester two weeks ago. Scott Staniforth returns on the right wing having recovered from injury, Geoff Appleford starts at outside centre on his return from playing for England in Hong Kong, and Darren Edwards takes over at scrum half.
Among the forwards Robbie Russell comes in at hooker after being with Scotland's squad in the Six Nations and Bob Casey returns in the second row after playing for the Ireland A team.
Irish are missing Delon Armitage (leg), Peter Poulos (knee) and Richard Skuse (neck) through injury.
Commenting on the game, Gary Gold, London Irish's head coach, said: "We have four Zurich Premiership games to go and because we are only 12 points adrift of fourth placed Bath, there's still time for us to make something of our season starting on Saturday with the visit of Gloucester.
"Despite all the recent setbacks, we know we can figure in the end-of-season play-offs and make the Heineken Cup next year. That remains our goal."
15. Michael Horak*; 14. Scott Staniforth*; 13. Geoff Appleford*; 12. Mike Catt*; 11. Justin Bishop*; 10. Barry Everitt; 9. Darren Edwards; 1. Neal Hatley; 2. Robbie Russell*; 3. Rob Hardwick*; 4. Ryan Strudwick (captain); 5. Bob Casey*; 6. Paul Gustard; 7. Kieron Dawson*; 8. Roland Reid*.
Replacements: 16. Doug Wheatley; 17. Adrian Flavin; 18. Nick Kennedy; 19. Declan Danaher; 20. Nils Mordt; 21. Mark Mapletoft*; 22. Paul Hodgson.
* Denotes international
Previewing Friday evening's local derby at Bristol, Interim Head Coach Jonny Bell told the local media that Gloucester's preparations have gone well and that the whole squad is united in trying to finish the season on a high.
Speaking to GRTV this week, Acting Head Coach Jonny Bell spoke of his pleasure in the efforts and intensity in training from the squad after a tricky few weeks. The team were preparing for big games with Bristol and Cardiff in coming weeks.
Willi Heinz was understandably and visibly disappointed when he spoke to GRTV after the 27-30 home defeat to Harlequins, apologising to the home support as the game slipped away after seemingly having the game under control.
Speaking to the local media this week, Scottish centre Matt Scott spoke of the squad's determination to put in a big home performance against Harlequins, with vital points up for grabs in the hunt for a Top Six spot this Saturday (KO 3pm)
Looking ahead to Saturday's Aviva Premiership fixture at home to Harlequins (kick off 3pm), Head Coach Laurie Fisher told the local media that Gloucester will need to be on top of their game in a match which has big implications in terms of top six ambitions.
A big few days for the Gloucester-Hartpury Women side. First came the news that the team will compete in Women's Super Rugby next season, and on Saturday the team will play Worcester Ladies IIs at Kingsholm. Centre Hannah Jones and wing Michelle Ruddock spoke to GRTV this week to reflect on events.
Missing so many starters, and up against a team fighting for their Premiership existence, Gloucester did what had to be done at Ashton Gate on Friday evening battling their way to a 32-14 Aviva Premiership win over Bristol Rugby.