London Irish have made five changes to the starting line-up for Gloucester's visit to the Madejski Stadium on Saturday 26 March (kick off 5pm).
The changes come on the back of the defeat to Leicester two weeks ago. Scott Staniforth returns on the right wing having recovered from injury, Geoff Appleford starts at outside centre on his return from playing for England in Hong Kong, and Darren Edwards takes over at scrum half.
Among the forwards Robbie Russell comes in at hooker after being with Scotland's squad in the Six Nations and Bob Casey returns in the second row after playing for the Ireland A team.
Irish are missing Delon Armitage (leg), Peter Poulos (knee) and Richard Skuse (neck) through injury.
Commenting on the game, Gary Gold, London Irish's head coach, said: "We have four Zurich Premiership games to go and because we are only 12 points adrift of fourth placed Bath, there's still time for us to make something of our season starting on Saturday with the visit of Gloucester.
"Despite all the recent setbacks, we know we can figure in the end-of-season play-offs and make the Heineken Cup next year. That remains our goal."
15. Michael Horak*; 14. Scott Staniforth*; 13. Geoff Appleford*; 12. Mike Catt*; 11. Justin Bishop*; 10. Barry Everitt; 9. Darren Edwards; 1. Neal Hatley; 2. Robbie Russell*; 3. Rob Hardwick*; 4. Ryan Strudwick (captain); 5. Bob Casey*; 6. Paul Gustard; 7. Kieron Dawson*; 8. Roland Reid*.
Replacements: 16. Doug Wheatley; 17. Adrian Flavin; 18. Nick Kennedy; 19. Declan Danaher; 20. Nils Mordt; 21. Mark Mapletoft*; 22. Paul Hodgson.
* Denotes international
Despite he and a number of his team mates playing out of position, Greig Laidlaw's four penalties were enough to help Gloucester to a 12-11 Aviva Premiership win at Sale on Friday evening. The skipper told GRTV after the game that everyone had played their part, especially the younger players.
Greig Laidlaw skippers the Cherry and Whites on Friday evening, when they head to Sale Sharks for the penultimate game of this season's Aviva Premiership. The Scottish half back spoke to GRTV about the challenge posed in Salford.
Previewing Friday night's Aviva Premiership fixture away at Sale Sharks, Head Coach Laurie Fisher acknowledged the fine home record that the Salford based outfit have built up this season, but is looking for Gloucester to round off their campaign on a high note.
Speaking to GRTV following the 16-9 victory over Exeter, Tom Savage felt that Gloucester needed that win after a tough few weeks and hopes that it acts as a springboard to a good end to the season for the Cherry and Whites.
A week on from '...letting down ourselves, the jersey and the supporters...', skipper Greig Laidlaw was full of praise for his team mates following the 16-9 Aviva Premiership win over Exeter Chiefs at Kingsholm on Friday evening.
Four penalties from the boot of skipper Greig Laidlaw were just enough to see Gloucester dog out a tense 12-11 win at Sale on Friday evening and thwart the home team's attempts to finish the season unbeaten at home.
Thirteen years on from Gloucester Rugby's famous Powergen Cup victory over Northampton at Twickenham, many of the players and management from that side are gathering once more to recreate that famous day.