London Irish have made five changes to the starting line-up for Gloucester's visit to the Madejski Stadium on Saturday 26 March (kick off 5pm).
The changes come on the back of the defeat to Leicester two weeks ago. Scott Staniforth returns on the right wing having recovered from injury, Geoff Appleford starts at outside centre on his return from playing for England in Hong Kong, and Darren Edwards takes over at scrum half.
Among the forwards Robbie Russell comes in at hooker after being with Scotland's squad in the Six Nations and Bob Casey returns in the second row after playing for the Ireland A team.
Irish are missing Delon Armitage (leg), Peter Poulos (knee) and Richard Skuse (neck) through injury.
Commenting on the game, Gary Gold, London Irish's head coach, said: "We have four Zurich Premiership games to go and because we are only 12 points adrift of fourth placed Bath, there's still time for us to make something of our season starting on Saturday with the visit of Gloucester.
"Despite all the recent setbacks, we know we can figure in the end-of-season play-offs and make the Heineken Cup next year. That remains our goal."
15. Michael Horak*; 14. Scott Staniforth*; 13. Geoff Appleford*; 12. Mike Catt*; 11. Justin Bishop*; 10. Barry Everitt; 9. Darren Edwards; 1. Neal Hatley; 2. Robbie Russell*; 3. Rob Hardwick*; 4. Ryan Strudwick (captain); 5. Bob Casey*; 6. Paul Gustard; 7. Kieron Dawson*; 8. Roland Reid*.
Replacements: 16. Doug Wheatley; 17. Adrian Flavin; 18. Nick Kennedy; 19. Declan Danaher; 20. Nils Mordt; 21. Mark Mapletoft*; 22. Paul Hodgson.
* Denotes international
Speaking to the local media this week, David Humphreys insisted that Gloucester are looking forward to kicking off the new European Rugby Challenge Cup against Brive on Thursday evening, although an unfamiliar opponent and a five day turnaround will pose a challenge.
Director of Rugby David Humphreys felt that his Gloucester side put themselves in a position to put Saracens under real pressure at Allianz Park on Saturday, praising his team's commitment and defence, while admitting that a lack of accuracy hit their chances in the second half.
Speaking to the local media at Allianz Park, Tom Savage was disappointed after the defeat at Saracens, but claimed Gloucester did plenty of good things and could've taken more than a losing bonus point.
In case you missed it, there was plenty of activity on the official Gloucester Rugby website following the 55-0 European Rugby Challenge Cup win over CA Brive, including a number of post match video interviews.