Phil Vickery takes over the Gloucester captaincy for Saturday's 13,000 sell-out West Country derby against Bath at Kingsholm.
28 year-old Vickery leads from the front row alongside Welsh international hooker Mefin Davies and England U21 prop Nick Wood.
Adam Eustace returns to the second row in place of Mark Cornwell. James Forrester is named in the back-row and teams up with Andy Hazell and Adam Balding, with Jake Boer being dropped from the squad.
Henry Paul moves to stand-off in place of Duncan McRae, who misses out through injury. Marcel Garvey claims back the number 14 shirt after missing the last two games with mumps.
James Simpson-Daniel starts at outside centre, with Tongan Seti Kiole starting on the other wing, making it six changes to the starting line-up following Gloucester's last outing away at NEC Harlequins.
Players unavailable include Gary Powell (ankle), Chris Fortey (ankle), Olivier Azam (shoulder), Simon Amor (shoulder), Ryan Lamb (England U19s) and Nathan Mauger, who has flown back to New Zealand following a family bereavement.
15. Jon Goodridge
14. Marcel Garvey
13. James Simpson-Daniel
12. Terry Fanolua
11. Seti Kiole
10. Henry Paul
9. Andy Gomarsall
1. Nick Wood
2. Mefin Davies
3. Phil Vickery (c)
4. Adam Eustace
5. Alex Brown
6. James Forrester
7. Andy Hazell
8. Adam Balding
16. Noel Curnier
17. Terry Sigley
18. Mark Cornwell
19. Peter Buxton
20. James Merriman
21. Alex Page
22. James Bailey
Speaking to the local media this week, David Humphreys insisted that Gloucester are looking forward to kicking off the new European Rugby Challenge Cup against Brive on Thursday evening, although an unfamiliar opponent and a five day turnaround will pose a challenge.
Director of Rugby David Humphreys felt that his Gloucester side put themselves in a position to put Saracens under real pressure at Allianz Park on Saturday, praising his team's commitment and defence, while admitting that a lack of accuracy hit their chances in the second half.
Speaking to the local media at Allianz Park, Tom Savage was disappointed after the defeat at Saracens, but claimed Gloucester did plenty of good things and could've taken more than a losing bonus point.
In case you missed it, there was plenty of activity on the official Gloucester Rugby website following the 55-0 European Rugby Challenge Cup win over CA Brive, including a number of post match video interviews.
The Cherry and Whites ran in seven tries in beating CA Brive 55-0 on Thursday night. An emphatic second half performance saw the hosts run in five tries to get the European campaign off to a flying start.