Phil Vickery takes over the Gloucester captaincy for Saturday's 13,000 sell-out West Country derby against Bath at Kingsholm.
28 year-old Vickery leads from the front row alongside Welsh international hooker Mefin Davies and England U21 prop Nick Wood.
Adam Eustace returns to the second row in place of Mark Cornwell. James Forrester is named in the back-row and teams up with Andy Hazell and Adam Balding, with Jake Boer being dropped from the squad.
Henry Paul moves to stand-off in place of Duncan McRae, who misses out through injury. Marcel Garvey claims back the number 14 shirt after missing the last two games with mumps.
James Simpson-Daniel starts at outside centre, with Tongan Seti Kiole starting on the other wing, making it six changes to the starting line-up following Gloucester's last outing away at NEC Harlequins.
Players unavailable include Gary Powell (ankle), Chris Fortey (ankle), Olivier Azam (shoulder), Simon Amor (shoulder), Ryan Lamb (England U19s) and Nathan Mauger, who has flown back to New Zealand following a family bereavement.
15. Jon Goodridge
14. Marcel Garvey
13. James Simpson-Daniel
12. Terry Fanolua
11. Seti Kiole
10. Henry Paul
9. Andy Gomarsall
1. Nick Wood
2. Mefin Davies
3. Phil Vickery (c)
4. Adam Eustace
5. Alex Brown
6. James Forrester
7. Andy Hazell
8. Adam Balding
16. Noel Curnier
17. Terry Sigley
18. Mark Cornwell
19. Peter Buxton
20. James Merriman
21. Alex Page
22. James Bailey
Skipper Billy Twelvetrees admitted that the Gloucester squad were disappointed and frustrated after losing at home to Exeter, regretting that Gloucester's own errors had given the Chiefs the upper hand.
David Humphreys spoke to the local press after the Gloucester Rugby team to face Exeter Chiefs on Friday was announced. Henry Purdy is making his Premiership debut for Gloucester and thoroughly deserves his chance says Humphreys.
Dan Murphy was part of a Gloucester pack which took a grip as the Sale game progressed and, ultimately, were rewarded with a late penalty try. The loose head prop says the team's improved scrummaging is down to a lot of hard work over the summer.
Gloucester clinched their first Aviva Premiership win of the season on Saturday, 34-27 over Sale Sharks, and scrum half Greig Laidlaw felt that the Kingsholm crowd played a massive part as they spurred the team on.
David Humphreys spoke to Gloucester Rugby TV after the 34-27 win over Sale Sharks at Kingsholm. The Director of Rugby praised the Kingsholm crowd for spurring the team on to a super second half comeback.
Speaking to Gloucester Rugby TV this week, Sione Kalamafoni is expecting a tough, physical battle against Sale Sharks as the Cherry and Whites return to Kingsholm for Round Two of the Aviva Premiership
The message from the Gloucester Rugby Ticket Office is that tickets still remain for this evening's Aviva Premiership game against Exeter Chiefs and that there are a large number of tickets to be collected on the night.