The 22 year-old wing has been out of action since the start of December after injuring a shoulder in the Heineken Cup clash with Cardiff Blues.
Commenting on www.gloucesterrugbyclub.com Simpson-Daniel, who knows Gloucester need to bag another consecutive win after last Saturday's victory over Worcester, said: "First and foremost I want to the Club to do well, and I want to have a run of games until the end of the season and finish it on a high."
Simpson-Daniel, who has also missed game time this season with a hamstring injury, is relishing the challenge in store on Saturday and is well aware of the threat from Harlequins' back three.
"They're a dangerous back three and they have some quick runners in there, but we've also got a good understanding in our team, and it should make for a good game of rugby.
"We can't afford to look ahead of Saturday's game at the moment. We know we need to put a good run of wins together, but nobody is looking past Saturday's trip to London."
Director of rugby Nigel Melville was pleased to see the return of Simpson-Daniel to full training, especially after Marcel Garvey missed the Worcester win with mumps.
"We might be missing some players to the internationals, but it's not as bad as in the Autumn. We've got Andy Gomarsall, Henry Paul and Duncan McRae, who were all unavailable back in November.
"Having those guys available is very important, particularly the return of James Simpson-Daniel. I think this point in the season is ideal for him because the ground is hardening up and it's a nice wide pitch at Quins, which is what he likes."
Melville has missed the creativity from the young winger in recent months, and added: "We have missed him as much as I thought we might because he is an exceptional player. He has huge ability and we just want to get him back and keep him fit."
Melville and coach Dean Ryan will name their team for Saturday's Premiership game at Quins on Friday morning.
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