Gloucester's Mefin Davies and Olly Morgan will also be in international action this weekend with Wales and England U21s respectively.
32 year-old Mefin Davies has been selected at hooker for Wales in their massive Six Nations opener against England and his Gloucester colleagues Andy Hazell, Phil Vickery and James Forrester.
Davies starts for Wales ahead of Robin McBryde, who has recently returned from injury. He starts alongside props Adam Jones and Gethin Jenkins.
Gloucester Academy star Olly Morgan is in contention for the full-back slot for England U21s against Wales in Newport on Friday night.
The 19 year-old has already represented England U19s. He was set for a full 80 minutes against Saracens in the Zurich 'A' League last week, but the game was postponed, but he went on to play for Bracknell in the national leagues last weekend.
WALES Vs ENGLAND
Millennium Stadium, Saturday 5th February, Kick-off: 5.30 pm
Wales: G Thomas (Toulouse (capt); H Luscombe (Dragons), T Shanklin (Blues), G Henson (Ospreys), S Williams (Ospreys); S Jones (Clermont Auvergne), D Peel (Scarlets); G Jenkins (Blues), M Davies (Gloucester), A Jones (Ospreys), B Cockbain (Ospreys), R Sidoli (Blues), D Jones (Scarlets), M Williams (Blues), M Owen (Dragons).
Replacements: R McBryde (Scarlets), J Yapp (Blues), J Thomas (Ospreys), R Jones (Ospreys), G Cooper (Dragons), C Sweeney (Dragons), K Morgan (Dragons).
England U21 squad to play Wales U21, Friday 4th February
Richard Blaze - Worcester*
Neil Briggs - Rotherham
Sean Cox - Sale Sharks
Chris Cracknell - NEC Harlequins
Aston Croall - Saracens
Michael Cusack - Leeds Tykes
Chris Goodman - Bath*
Martin Halsall - Sale Sharks
Matt Hampson - Leicester Tigers
James Haskell - London Wasps*
Tom Rees - London Wasps
Dan Smith - Bath
David Ward - Bath
Joe Bedford - Saracens*
Ross Broadfoot - Leicester Tigers
Matt Cornwell - Leicester Tigers
Ryan Davis - Bath*
Ben Foden - Sale Sharks
Olly Morgan - Gloucester*
Tom Varndell - Leicester Tigers*
James Wellwood - London Wasps
Simon Whatling - Worcester
* Intermediate National Academy squad member
England U21 Six Nations fixtures
England U21 v Wales U21, Friday 4th February, Newport 7.05pm
England U21s v France U21, Friday 11th February, Northampton Saints 7.30pm
England U21s v Ireland U21, Friday 25th February, Donnybrook 7.30pm
England U21s v Italy U21, Friday 11th March, Northampton Saints 7.30pm
England U21s v Scotland U21, Friday 18th March, Northampton Saints 7.30pm
Gary Jones of Glevum Windows and Conservatories recently visited Kingsholm Stadium and the Cherry and White supporter spoke exclusively to Gloucester Rugby TV after marking two decades as a box holder in the Stowford Press Stand at Kingsholm. A great feat!
Speaking to the local media this week during preseason, new hooker Richard Hibbard said he was really enjoying putting in the hard work and being back to full fitness ahead of the 2014-15 season with the Cherry and Whites.
Nick Walshe was unveiled as Gloucester's new Backs and Attack Coach this week and spoke to Simon Ward for the RFU.com podcast about his excitement at joining Gloucester and working with a new group of players.
Speaking after the Third Test defeat to New Zealand, Ben Morgan told RFU.com that the loss was a disappointing way to sign off the summer tour but that the England team know what they have to do to be successful.
At the end of a tour when there have been so many positives for England, fly half Freddie Burns, who will start the third Test against New Zealand, was clear that the whole squad are focussed on signing off with a memorable win when he spoke to RFU.com
Speaking to Steve Jones of RFU.com straight after the 27-28 defeat to New Zealand on Saturday, Billy Twelvetrees spoke of the frustration of a missed opportunity, but stressed that England would lick their wounds and bounce back.
Freddie Burns contributed 12 points in England's 20-15 defeat against New Zealand on Saturday but, speaking after the game to RFU.com, preferred to talk about the many positives in the performance from Stuart Lancaster's side.
Gloucester number eight Ben Morgan put in a great individual performance as England were just pipped by New Zealand by 20 points to 15 in Auckland on Saturday. He told Steve Jones of RFU.com that the team will be in good spirits going into the 2nd Test in Dunedin.
It's been marked in the diary since the spring, but rugby will be returning to Kingsholm on July 31st. The holders host the Premiership Rugby Sevens for the third consecutive year, and Dan Robson can't wait to get on the field with the new look squad.