Gloucester's Mefin Davies and Olly Morgan will also be in international action this weekend with Wales and England U21s respectively.
32 year-old Mefin Davies has been selected at hooker for Wales in their massive Six Nations opener against England and his Gloucester colleagues Andy Hazell, Phil Vickery and James Forrester.
Davies starts for Wales ahead of Robin McBryde, who has recently returned from injury. He starts alongside props Adam Jones and Gethin Jenkins.
Gloucester Academy star Olly Morgan is in contention for the full-back slot for England U21s against Wales in Newport on Friday night.
The 19 year-old has already represented England U19s. He was set for a full 80 minutes against Saracens in the Zurich 'A' League last week, but the game was postponed, but he went on to play for Bracknell in the national leagues last weekend.
WALES Vs ENGLAND
Millennium Stadium, Saturday 5th February, Kick-off: 5.30 pm
Wales: G Thomas (Toulouse (capt); H Luscombe (Dragons), T Shanklin (Blues), G Henson (Ospreys), S Williams (Ospreys); S Jones (Clermont Auvergne), D Peel (Scarlets); G Jenkins (Blues), M Davies (Gloucester), A Jones (Ospreys), B Cockbain (Ospreys), R Sidoli (Blues), D Jones (Scarlets), M Williams (Blues), M Owen (Dragons).
Replacements: R McBryde (Scarlets), J Yapp (Blues), J Thomas (Ospreys), R Jones (Ospreys), G Cooper (Dragons), C Sweeney (Dragons), K Morgan (Dragons).
England U21 squad to play Wales U21, Friday 4th February
Richard Blaze - Worcester*
Neil Briggs - Rotherham
Sean Cox - Sale Sharks
Chris Cracknell - NEC Harlequins
Aston Croall - Saracens
Michael Cusack - Leeds Tykes
Chris Goodman - Bath*
Martin Halsall - Sale Sharks
Matt Hampson - Leicester Tigers
James Haskell - London Wasps*
Tom Rees - London Wasps
Dan Smith - Bath
David Ward - Bath
Joe Bedford - Saracens*
Ross Broadfoot - Leicester Tigers
Matt Cornwell - Leicester Tigers
Ryan Davis - Bath*
Ben Foden - Sale Sharks
Olly Morgan - Gloucester*
Tom Varndell - Leicester Tigers*
James Wellwood - London Wasps
Simon Whatling - Worcester
* Intermediate National Academy squad member
England U21 Six Nations fixtures
England U21 v Wales U21, Friday 4th February, Newport 7.05pm
England U21s v France U21, Friday 11th February, Northampton Saints 7.30pm
England U21s v Ireland U21, Friday 25th February, Donnybrook 7.30pm
England U21s v Italy U21, Friday 11th March, Northampton Saints 7.30pm
England U21s v Scotland U21, Friday 18th March, Northampton Saints 7.30pm
Huia Edmonds spoke to Gloucester Rugby TV this week ahead of Gloucester's clash with London Wasps in #TheStinger. The Australian hooker is yet to play at Twickenham and is excited at the prospect and putting things right on the pitch.
The bitter disappointment of losing against London Wasps in the Amlin Challenge Cup less than a fortnight ago, will give Gloucester ample motivation against the same opponent at Twickenham on Saturday says Director of Rugby Nigel Davies.
Billy Twelvetrees spoke to Gloucester Rugby TV following the 17-18 loss to Bath Rugby in Round Nineteen of Aviva Premiership Rugby. The Gloucester skipper said he was proud of the desire shown by his team at the end of a tough afternoon.
Nigel Davies spoke to Gloucester Rugby TV following the gutting 17-18 reverse to Bath on Saturday afternoon. The Director of Rugby expressed his pride at the efforts from his players and thanked the supporters for their incredible backing.
Nick Wood spoke to Gloucester Rugby TV this week ahead of Saturday's West Country derby clash with Bath Rugby. The front rower called on the squad to make a strong start and get the Kingsholm crowd behind them
Director of Rugby Nigel Davies admits that it's been a tough week at Gloucester Rugby following defeat at London Wasps last weekend, but that he's looking for his team to rise to the occasion for the huge game at home to Bath Rugby on Saturday.
Speaking immediately after the 36-24 Amlin Challenge Cup defeat at London Wasps on Sunday evening, skipper Billy Twelvetrees admitted that Gloucester left themselves with too much to do despite a spirited second half comeback.
Nigel Davies spoke to Gloucester Rugby TV following the 36-24 defeat to London Wasps in the Amlin Challenge Cup Quarter Final. The Director of Rugby rued a lacklustre showing the first half despite a big second half display with ultimately came to nothing on a hugely frustrating night for the Cherry and Whites.
Gloucester Rugby's trip to Twickenham ended in a 38-30 defeat to London Wasps in the sunshine. The hosts ran in 5 tries to Gloucester's three on a tough afternoon that despite plenty of promise saw Gloucester let down by errors.
England Under 18s have named their side to take on Ireland in the final of the FIRA/AER European Championship as they bid for a third consecutive title in Wronki, Poland, on Saturday, kick off 3.30pm BST.
Ahead of this weekend's trip to Twickenham for The Stinger, there are plenty of videos on the way to preview the fixture vs London Wasps, as well as video reaction and unique Go Pro videos from the last 7 days of action.