Gloucester's Mefin Davies and Olly Morgan will also be in international action this weekend with Wales and England U21s respectively.
32 year-old Mefin Davies has been selected at hooker for Wales in their massive Six Nations opener against England and his Gloucester colleagues Andy Hazell, Phil Vickery and James Forrester.
Davies starts for Wales ahead of Robin McBryde, who has recently returned from injury. He starts alongside props Adam Jones and Gethin Jenkins.
Gloucester Academy star Olly Morgan is in contention for the full-back slot for England U21s against Wales in Newport on Friday night.
The 19 year-old has already represented England U19s. He was set for a full 80 minutes against Saracens in the Zurich 'A' League last week, but the game was postponed, but he went on to play for Bracknell in the national leagues last weekend.
WALES Vs ENGLAND
Millennium Stadium, Saturday 5th February, Kick-off: 5.30 pm
Wales: G Thomas (Toulouse (capt); H Luscombe (Dragons), T Shanklin (Blues), G Henson (Ospreys), S Williams (Ospreys); S Jones (Clermont Auvergne), D Peel (Scarlets); G Jenkins (Blues), M Davies (Gloucester), A Jones (Ospreys), B Cockbain (Ospreys), R Sidoli (Blues), D Jones (Scarlets), M Williams (Blues), M Owen (Dragons).
Replacements: R McBryde (Scarlets), J Yapp (Blues), J Thomas (Ospreys), R Jones (Ospreys), G Cooper (Dragons), C Sweeney (Dragons), K Morgan (Dragons).
England U21 squad to play Wales U21, Friday 4th February
Richard Blaze - Worcester*
Neil Briggs - Rotherham
Sean Cox - Sale Sharks
Chris Cracknell - NEC Harlequins
Aston Croall - Saracens
Michael Cusack - Leeds Tykes
Chris Goodman - Bath*
Martin Halsall - Sale Sharks
Matt Hampson - Leicester Tigers
James Haskell - London Wasps*
Tom Rees - London Wasps
Dan Smith - Bath
David Ward - Bath
Joe Bedford - Saracens*
Ross Broadfoot - Leicester Tigers
Matt Cornwell - Leicester Tigers
Ryan Davis - Bath*
Ben Foden - Sale Sharks
Olly Morgan - Gloucester*
Tom Varndell - Leicester Tigers*
James Wellwood - London Wasps
Simon Whatling - Worcester
* Intermediate National Academy squad member
England U21 Six Nations fixtures
England U21 v Wales U21, Friday 4th February, Newport 7.05pm
England U21s v France U21, Friday 11th February, Northampton Saints 7.30pm
England U21s v Ireland U21, Friday 25th February, Donnybrook 7.30pm
England U21s v Italy U21, Friday 11th March, Northampton Saints 7.30pm
England U21s v Scotland U21, Friday 18th March, Northampton Saints 7.30pm
Ben Morgan starts at number eight for England on Sunday afternoon as the Red Rose take on Wales at Twickenham (kick off 3pm). The Gloucester back-rower spoke with Gloucester Rugby TV at Pennyhill Park as he and his international colleagues prepared for the eagerly anticipated RBS Six Nations' clash.
Billy Twelvetrees spoke to Russ Hargreaves of Talking Rugby at England training ahead of Sunday's huge RBS Six Nations clash with Wales at Twickenham. The centre is relishing the challenge of fronting up against a smart and talented Welsh back line.
Tim Taylor spoke to Gloucester Rugby TV after the 31 year old fly half announced that he was retiring from professional rugby. The Derby-born pivot, is excited for what the future holds for his new business ventures despite his career being cut short by a knee injury.
Dan Robson spoke to Gloucester Rugby TV at Franklin's Gardens following the 39-13 loss to Saints. The scrum-half enjoyed his battle with Lee Dickson but was gutted at the result as the Cherry and Whites did not do themselves justice, falling off in the closing stages to the league leaders.
Speaking after the game at Franklin's Gardens, Director of Rugby Nigel Davies reflected on a disappointing final quarter which saw Northampton Saints ease their way to a comfortable 39-13 win on Saturday afternoon.
Gloucester Rugby TV caught up with Gareth Evans this week ahead of the trip to Northampton Saints in the Aviva Premiership. The back rower explained his pride in his performances this season but knows there is still a lot for him to learn.
Gloucester Rugby travel to take on the table topping Northampton Saints in the Aviva Premiership on Saturday. Director of Rugby Nigel Davies is well aware of the qualities of Jim Mallinder's side, but Gloucester are the only team to defeat the Saints in the league this season.
Gloucester number eight Ben Morgan is hoping to start against Wales a week on Sunday, a team containing a number of former club team mates. He told the RFU.com website that he's looking forward to the prospect.
After adverse weather caused the Road to 2015 sponsored walk to be postponed from Sunday 9 February, Gloucester Rugby are pleased to announce that the new date has now been confirmed as Saturday 3 May.
Gloucester Rugby Community department are holding a silent auction for a mascot package for the Gloucester v London Irish match on Saturday 3rd May 2014, 3pm kick off, kindly donated by our match day mascot sponsor Rendcomb College.