Gloucester's Mefin Davies and Olly Morgan will also be in international action this weekend with Wales and England U21s respectively.
32 year-old Mefin Davies has been selected at hooker for Wales in their massive Six Nations opener against England and his Gloucester colleagues Andy Hazell, Phil Vickery and James Forrester.
Davies starts for Wales ahead of Robin McBryde, who has recently returned from injury. He starts alongside props Adam Jones and Gethin Jenkins.
Gloucester Academy star Olly Morgan is in contention for the full-back slot for England U21s against Wales in Newport on Friday night.
The 19 year-old has already represented England U19s. He was set for a full 80 minutes against Saracens in the Zurich 'A' League last week, but the game was postponed, but he went on to play for Bracknell in the national leagues last weekend.
WALES Vs ENGLAND
Millennium Stadium, Saturday 5th February, Kick-off: 5.30 pm
Wales: G Thomas (Toulouse (capt); H Luscombe (Dragons), T Shanklin (Blues), G Henson (Ospreys), S Williams (Ospreys); S Jones (Clermont Auvergne), D Peel (Scarlets); G Jenkins (Blues), M Davies (Gloucester), A Jones (Ospreys), B Cockbain (Ospreys), R Sidoli (Blues), D Jones (Scarlets), M Williams (Blues), M Owen (Dragons).
Replacements: R McBryde (Scarlets), J Yapp (Blues), J Thomas (Ospreys), R Jones (Ospreys), G Cooper (Dragons), C Sweeney (Dragons), K Morgan (Dragons).
England U21 squad to play Wales U21, Friday 4th February
Richard Blaze - Worcester*
Neil Briggs - Rotherham
Sean Cox - Sale Sharks
Chris Cracknell - NEC Harlequins
Aston Croall - Saracens
Michael Cusack - Leeds Tykes
Chris Goodman - Bath*
Martin Halsall - Sale Sharks
Matt Hampson - Leicester Tigers
James Haskell - London Wasps*
Tom Rees - London Wasps
Dan Smith - Bath
David Ward - Bath
Joe Bedford - Saracens*
Ross Broadfoot - Leicester Tigers
Matt Cornwell - Leicester Tigers
Ryan Davis - Bath*
Ben Foden - Sale Sharks
Olly Morgan - Gloucester*
Tom Varndell - Leicester Tigers*
James Wellwood - London Wasps
Simon Whatling - Worcester
* Intermediate National Academy squad member
England U21 Six Nations fixtures
England U21 v Wales U21, Friday 4th February, Newport 7.05pm
England U21s v France U21, Friday 11th February, Northampton Saints 7.30pm
England U21s v Ireland U21, Friday 25th February, Donnybrook 7.30pm
England U21s v Italy U21, Friday 11th March, Northampton Saints 7.30pm
England U21s v Scotland U21, Friday 18th March, Northampton Saints 7.30pm
Speaking to the local media this week, Richard Hibbard expressed his excitement ahead of the West Country derby and that there is an extra spring in the step of the Cherry and Whites ahead of the tough challenge.
With such a short turnaround between the two games, and Gloucester looking to reintegrate several players into the line-up after the Autumn international series, Tom Savage told GRTV that the Cherry and Whites will keep changes to a minimum for the European Rugby Challenge Cup game in Zebre on Saturday.
Gloucester travel to Italy this weekend to take on Zebre in Round Four of the European Rugby Challenge Cup. The Cherry and Whites defeated the Italian side 35-10 last Sunday, but Director of Rugby David Humphreys is looking for an improved performance in the return fixture.
On a tough evening at Kingsholm, Gloucester could escape neither a suffocating Bath defence, nor the whistle of referee Greg Garner as six penalties and a penalty try paved the way to a 39-16 win for the visitors.
Gloucester Rugby welcome Sione Kalamafoni, Greig Laidlaw and Tom Palmer back to the starting line up and feature David Halaifonua in a matchday squad for the first time, as they resume Aviva Premiership action against Bath Rugby at Kingsholm on Saturday (kick off 5:30pm).