Gloucester's Mefin Davies and Olly Morgan will also be in international action this weekend with Wales and England U21s respectively.
32 year-old Mefin Davies has been selected at hooker for Wales in their massive Six Nations opener against England and his Gloucester colleagues Andy Hazell, Phil Vickery and James Forrester.
Davies starts for Wales ahead of Robin McBryde, who has recently returned from injury. He starts alongside props Adam Jones and Gethin Jenkins.
Gloucester Academy star Olly Morgan is in contention for the full-back slot for England U21s against Wales in Newport on Friday night.
The 19 year-old has already represented England U19s. He was set for a full 80 minutes against Saracens in the Zurich 'A' League last week, but the game was postponed, but he went on to play for Bracknell in the national leagues last weekend.
WALES Vs ENGLAND
Millennium Stadium, Saturday 5th February, Kick-off: 5.30 pm
Wales: G Thomas (Toulouse (capt); H Luscombe (Dragons), T Shanklin (Blues), G Henson (Ospreys), S Williams (Ospreys); S Jones (Clermont Auvergne), D Peel (Scarlets); G Jenkins (Blues), M Davies (Gloucester), A Jones (Ospreys), B Cockbain (Ospreys), R Sidoli (Blues), D Jones (Scarlets), M Williams (Blues), M Owen (Dragons).
Replacements: R McBryde (Scarlets), J Yapp (Blues), J Thomas (Ospreys), R Jones (Ospreys), G Cooper (Dragons), C Sweeney (Dragons), K Morgan (Dragons).
England U21 squad to play Wales U21, Friday 4th February
Richard Blaze - Worcester*
Neil Briggs - Rotherham
Sean Cox - Sale Sharks
Chris Cracknell - NEC Harlequins
Aston Croall - Saracens
Michael Cusack - Leeds Tykes
Chris Goodman - Bath*
Martin Halsall - Sale Sharks
Matt Hampson - Leicester Tigers
James Haskell - London Wasps*
Tom Rees - London Wasps
Dan Smith - Bath
David Ward - Bath
Joe Bedford - Saracens*
Ross Broadfoot - Leicester Tigers
Matt Cornwell - Leicester Tigers
Ryan Davis - Bath*
Ben Foden - Sale Sharks
Olly Morgan - Gloucester*
Tom Varndell - Leicester Tigers*
James Wellwood - London Wasps
Simon Whatling - Worcester
* Intermediate National Academy squad member
England U21 Six Nations fixtures
England U21 v Wales U21, Friday 4th February, Newport 7.05pm
England U21s v France U21, Friday 11th February, Northampton Saints 7.30pm
England U21s v Ireland U21, Friday 25th February, Donnybrook 7.30pm
England U21s v Italy U21, Friday 11th March, Northampton Saints 7.30pm
England U21s v Scotland U21, Friday 18th March, Northampton Saints 7.30pm
Speaking to GRTV in front of the iconic Clifton Suspension Bridge, Henry Trinder explained how important the West Country Challenge Cup is going to be for the Cherry and Whites in their preseason preparations.
Speaking to GRTV at preseason training this Tuesday, new signing Willi Heinz gave an update on his recovery from a leg injury and expressed his enjoyment since his arrival in new surroundings with Gloucester Rugby.
Speaking to GRTV after the 22-23 defeat against Bordeaux-Begles which denied Gloucester a place in next season's European Rugby Champions Cup, Nick Wood rued the momentary lapse in concentration which allowed the French side to snatch victory from the jaws of defeat.
As Gloucester prepare for their 39th game of the season, against Bordeaux-Begles at Sixways on Sunday, David Humphreys told the local media that this week has been all about getting the players mentally and physically ready after a tough game against Connacht last Sunday.
England Rugby 2015, has today launched its travel demand campaign to help fans, residents and local businesses beat the Rugby crowds during Rugby World Cup 2015, which takes place from September 18 to October 31.
Gloucester Rugby and Scotland scrum half Greig Laidlaw is gearing up for Rugby World Cup with his international teammates, and speaking to the assembled media this week, Laidlaw is excited to be in familiar surroundings at the showcase tournament.
With 50 days to go until Rugby World Cup 2015 gets underway several of the nations that are set to take to the Kingsholm Stadium field during the pool stages were in action in Toronto in Round Three of the Pacific Nations Cup.