Bristol travel to Gloucester for Saturday's 13,000 sell-out.
Bristol Shoguns have made one change to their line-up for Saturday's Powergen Cup clash, bringing in former Scottish international David Hilton for Alex Clarke at loosehead prop.
Bristol coach Richard Hill, the former Gloucester director of rugby, said: "The front row with Dave Hilton coming in is just a normal rotational change. Alex Clarke and Dave Hilton have been playing equally well so, what we tend to do, is give them two games each.
"Jason Hobson keeps his place. Darren Crompton bruised his ribs at London Welsh so missed Sedgley Park and is not quite right for this one.
"Bernardo Stortoni is also still out with a tweak to a knee ligament which isn't quite right for this weekend but he'll be ok for next weekend. So, Matt Salter, Darren Crompton and Bernardo Stortoni are the three injuries we have on our list but all three we hope are just one or two weeks away.
"Unusually we've had little or no discussion about Gloucester this week. We're planning for the next two to three weeks of the league programme and Exeter particularly on Feb 5th. It's been good in a way because I haven't heard a lot of talk about Gloucester.
"The first 20 minutes will be absolutely crucial because they'll have had a kick up the backside, I imagine. Words like 'The Gloucester forwards have lost the respect of the Kingsholm crowd' that have come out of the mouth of Nigel Melville will have hurt.
"We know we've got a huge job and they'll have been stung into action. But, if we can be close to them after 20 minutes, I think the crowd will get a little bit restless and one or two doubts might creep in. That's all we can hope for.
"It'll either be completely over for us after 20 minutes or there'll be a very interesting game in prospect. If we do make it to the Premiership and we're looking to retain players, we have to be sure that they're capable of taking it up to the next level."
Recent signings, scrum half Hentie Martens, fly-half Mark Woodrow and flanker Craig Short are all 'Cup-tied'
Bristol Shoguns team
15 Sean Marsden
14 Marko Stanojevic
13 Rob Higgitt
12 Sam Cox
11 Luke Nabaro
10 Jason Strange
9 Ross Blake
1 Dave Hilton
2 Saul Nelson
3 Jason Hobson
4 Ed Pearce
5 Ollie Hodge
6 Chris Morgan
7 Joe El-Abd (Capt.)
8 Jim Brownrigg
16 Greg Nicholls
17 Jonathan Pritchard
18 Adam Billig
19 Alex Clarke
20 Neil Clark
21 Rik Martin-Redman
22 Olly Kohn
Willi Heinz scored Gloucester's second try as the Cherry and Whites overturned a disappointing first 40 minutes and 0-6 half time deficit, to earn a 26-18 Aviva Premiership victory over Bristol Rugby on Saturday.
It's the first Gloucester-Bristol derby at Kingsholm in over eight years this Saturday (kick off 4:30pm) and, previewing the game with the local media this week, Defence Coach Jonny Bell stressed that, with both teams in the bottom half of the table, they both need the points.
Speaking to the local media this week, Gloucester front rower John Afoa knows the challenge ahead this week against Bristol, and calls on the Cherry and Whites to make the most of home advantage as a determined squad look to bounce back from a narrow loss to Saracens.
Tom Savage speaks to GRTV and the local media as Gloucester went down by 24-20 at Saracens on Sunday afternoon. The second row was disappointed with the result, despite a strong showing from the hosts.
Speaking immediately after the game, skipper Willi Heinz thought that Gloucester had executed their game plan reasonably well and competed hard against Saracens. However, it wasn't enough but the squad will have plenty to work on this week ahead of the derby match against Bristol.
Gloucester may be coming off their best win of the season, the 38-16 victory over Wasps last weekend, but Director of Rugby David Humphreys admits that Sunday's trip to Saracens is an even tougher test.
Looking to try a new sport? Look no further than Walking Rugby as thanks to Gloucester Rugby you can come along and try out the fast-growing sport at taster sessions across the county, starting this Wednesday.
Gloucester return to European Rugby Challenge Cup action on Thursday evening with the visit of Stade Rochelais to Kingsholm (kick off 7:45pm). Early Bird ticket prices are available until 6:30pm on matchday.
Talk about a game of two halves. Things looked grim on Saturday as Gloucester trailed 0-6 to Bristol at half-time. However, Matt Scott's eighth try of the season got Gloucester off and running, and the visitors fell apart as the Cherry and Whites eased to a 26-18 bonus point Aviva Premiership win.