Loose-head prop Terry Sigley and Welsh international hooker Mefin Davies come into the front row alongside Phil Vickery. Both James Parkes and Christo Bezuidenhout move to the bench.
32 year-old Davies missed the last two European games as he signed for Gloucester after the Heineken Cup registration deadline.
Adam Balding starts at number eight in place of James Forrester, and Seti Kiole comes in on the left wing after James Simpson-Daniel was ruled out earlier in the week.
Jon Goodridge and Marcel Garvey continue a superb sequence of appearances that has seen both of them start every single one of Gloucester's 21 games (including this weekend) this season.
Mark Foster comes on to the bench, alongside Nathan Mauger and Alex Page as cover for the backs.
The game is a 13,000 sell-out and tickets sold out two weeks ago. The game will be shown live on BBC1 in the West and West Midlands regions. Supporters outside of these two regions can also watch the match through Sky digital.
Gloucester:
15. Jon Goodridge
14. Marcel Garvey
13. Terry Fanolua
12. Henry Paul
11. Seti Kiole
10. Duncan McRae
9. Andy Gomarsall
1. Terry Sigley
2. Mefin Davies
3. Phil Vickery
4. Adam Eustace
5. Alex Brown
6. Jake Boer (c)
7. Andy Hazell
8. Adam Balding
Replacements:
16. James Parkes, 17. Christo Bezuidenhout, 18. Peter Buxton, 19. James Forrester, 20. Alex Page, 21. Nathan Mauger, 22. Mark Foster
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