Nigel Melville makes four changes to the Gloucester starting line-up for Saturday's 13,000 capacity Powergen Cup quarter-final against Bristol Shoguns at Kingsholm (kick off 2.45pm).
Loose-head prop Terry Sigley and Welsh international hooker Mefin Davies come into the front row alongside Phil Vickery. Both James Parkes and Christo Bezuidenhout move to the bench.
32 year-old Davies missed the last two European games as he signed for Gloucester after the Heineken Cup registration deadline.
Adam Balding starts at number eight in place of James Forrester, and Seti Kiole comes in on the left wing after James Simpson-Daniel was ruled out earlier in the week.
Jon Goodridge and Marcel Garvey continue a superb sequence of appearances that has seen both of them start every single one of Gloucester's 21 games (including this weekend) this season.
Mark Foster comes on to the bench, alongside Nathan Mauger and Alex Page as cover for the backs.
The game is a 13,000 sell-out and tickets sold out two weeks ago. The game will be shown live on BBC1 in the West and West Midlands regions. Supporters outside of these two regions can also watch the match through Sky digital.
15. Jon Goodridge
14. Marcel Garvey
13. Terry Fanolua
12. Henry Paul
11. Seti Kiole
10. Duncan McRae
9. Andy Gomarsall
1. Terry Sigley
2. Mefin Davies
3. Phil Vickery
4. Adam Eustace
5. Alex Brown
6. Jake Boer (c)
7. Andy Hazell
8. Adam Balding
16. James Parkes, 17. Christo Bezuidenhout, 18. Peter Buxton, 19. James Forrester, 20. Alex Page, 21. Nathan Mauger, 22. Mark Foster
Speaking with the local media before the Gloucester team set off on the long trip north to Newcastle, Director of Rugby David Humphreys discussed his team selection and stated that Friday night's meeting will be a challenging one.
Speaking to the local media on Thursday, Matt Kvesic was looking forward to the trip to Newcastle Falcons, and the captain is looking to lead from the front with plenty for the Cherry and Whites to work on.
Gloucester saw a 12-0 lead overturned by Harlequins on Friday night as the visitors ran out 22-15 winners. After the game, Director of Rugby David Humphreys spoke about missed opportunities on the night.
Speaking to the local media on Thursday, James Hudson explained his excitement for tonight's game with Harlequins and that he is backing the Cherry and White squad to impress during the next set of Aviva Premiership games.
Despite a dream start at Kingston Park, scoring a try after just 26 seconds, Gloucester couldn't capitalise against a dogged Newcastle Falcons side. Too many penalties were conceded and too many errors made as the Falcons prevailed 20-10.
There are three changes to Gloucester Rugby's starting line-up for Friday evening's Aviva Premiership fixture away at Newcastle Falcons. Steve McColl will make his first Premiership start for the club.