Nigel Melville makes four changes to the Gloucester starting line-up for Saturday's 13,000 capacity Powergen Cup quarter-final against Bristol Shoguns at Kingsholm (kick off 2.45pm).
Loose-head prop Terry Sigley and Welsh international hooker Mefin Davies come into the front row alongside Phil Vickery. Both James Parkes and Christo Bezuidenhout move to the bench.
32 year-old Davies missed the last two European games as he signed for Gloucester after the Heineken Cup registration deadline.
Adam Balding starts at number eight in place of James Forrester, and Seti Kiole comes in on the left wing after James Simpson-Daniel was ruled out earlier in the week.
Jon Goodridge and Marcel Garvey continue a superb sequence of appearances that has seen both of them start every single one of Gloucester's 21 games (including this weekend) this season.
Mark Foster comes on to the bench, alongside Nathan Mauger and Alex Page as cover for the backs.
The game is a 13,000 sell-out and tickets sold out two weeks ago. The game will be shown live on BBC1 in the West and West Midlands regions. Supporters outside of these two regions can also watch the match through Sky digital.
15. Jon Goodridge
14. Marcel Garvey
13. Terry Fanolua
12. Henry Paul
11. Seti Kiole
10. Duncan McRae
9. Andy Gomarsall
1. Terry Sigley
2. Mefin Davies
3. Phil Vickery
4. Adam Eustace
5. Alex Brown
6. Jake Boer (c)
7. Andy Hazell
8. Adam Balding
16. James Parkes, 17. Christo Bezuidenhout, 18. Peter Buxton, 19. James Forrester, 20. Alex Page, 21. Nathan Mauger, 22. Mark Foster
Speaking after the game, Charlie Sharples described it as 'the win that has eluded us.' The winger stressed that Gloucester had stayed positive after the first couple of weeks of the Aviva Premiership season and the 26-13 victory over Sale was a result of that focus.
Gloucester Rugby picked up their first win of the new Aviva Premiership season on Friday night, easing to a 26-13 win on the road at Sale Sharks. Director of Rugby David Humphreys was full of praise for his players on the night.
Defence Coach Jonny Bell was on media duties ahead of the Aviva Premiership fixture at Sale Sharks on Friday evening, and spoke about where Gloucester find themselves in terms of their form at the moment as well as how he's viewing their defensive displays so far.
Callum Braley, who skippered Gloucester United to a 22-19 Aviva Premiership A League win over Saracens Storm on Monday evening, paid tribute to his forwards and the younger players in what he described as not the prettiest of wins.
Tickets for Saturday's Aviva Premiership game against Bath Rugby in both the Stowford Press Terrace and also The Shed are now in short supply, although a number of returns from the visitors have just gone back on sale.
A desperately disappointing afternoon for Gloucester who, despite dominating possession and territory, were guilty of failing to make the most of it against a resolute Newcastle defence before the visitors pounced to snatch the win in the second half.