Andy Hazell (head), Phil Vickery (arm), Marcel Garvey (elbow) and Terry Fanolua (back) are all missing, along with long term injured Henry Paul (knee), Chris Fortey (ankle) and Mark Cornwell (neck).
Mark Foster starts on the wing in place of Marcel Garvey, who injured his elbow against Leeds. The 21 year-old started at inside centre against the Tykes last weekend, and completes a back three of Seti Kiole and Jon Goodridge for the game at the Sharks.
Nathan Mauger comes in to the centres to partner James Simpson-Daniel, with Terry Fanolua still ruled out with a back injury.
Former England U21 fly-half Brad Davies partners Andy Gomarsall at half-back, with Duncan McRae starting from the bench (Gloucester have two overseas players - McRae and Mauger - and regulations state only one can be on the field at one time).
Nick Wood returns to the side in the front row alongside Mefin Davies and Gary Powell, and Adam Eustace and Alex Brown continuing in the second row.
Andy Hazell hasn't recovered from the knock to the head he took in the win over London Irish three weeks ago, and Academy product Luke Narraway wears the number seven shirt. Jake Boer moves from open-side to blind-side.
Captain Adam Balding is also back after missing last weekend against Leeds, with Peter Buxton and James Forrester named on the bench.
The replacements bench is completed with Olivier Azam, Terry Sigley, Alex Page, Duncan McRae and Olly Morgan.
Gloucester:
15. Jon Goodridge
14. Mark Foster
13. James Simpson-Daniel
12. Nathan Mauger
11. Seti Kiole
10. Brad Davies
9. Andy Gomarsall
1. Nick Wood
2. Mefin Davies
3. Gary Powell
4. Adam Eustace
5. Alex Brown
6. Jake Boer
7. Luke Narraway
8. Adam Balding (c)
Replacements:
16. Olivier Azam
17. Terry Sigley
18. Peter Buxton
19. James Forrester
20. Alex Page
21. Duncan McRae
22. Olly Morgan
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