The England centre will be the central figure as the Kingsholm club aim for their first ever league victory at the Rec.
Head coach Dean Ryan has recalled seven players to his side following their Powergen Cup victory over Bristol last weekend - but there is no place for hooker Olivier Azam because of a shoulder injury picked up at the Memorial Stadium.
His place on the bench is taken by James Parkes but otherwise Ryan is drawing from a fully fit squad who will look to consolidate their position in the top three of the Guinness Premiership.
Up front, Mefin Davies takes the number two shirt and there are also returns for England trio Alex Brown, flanker Andy Hazell and number eight James Forrester.
In the backs, Tindall will partner Henry Paul in Gloucester's tried and trusted centre pairing, while Mark Foster is preferred on the wing to Marcel Garvey.
But all eyes will be on Tindall as he makes his first return to his former club following his summer switch to Kingsholm.
"You always want to play well when you go back to your old club," he told www.gloucesterrugby.co.uk. "You always want to be fit, play well and win. Hopefully all those things will happen on Saturday.
"We know it's a massive game. In past seasons Gloucester have been the form team going down there but let themselves down a little.
"Since the start of the season we've said we don't mind losing to a better team, as long we as don't let ourselves down. The main thing for us is that we can put in a performance we can be proud of.
"If we can get everything right that we've done in the last five games and build on that as we've still got to improve in a lot of areas, then it's going to be a close game.
Bath played a lot better against the Ospreys, their attack was a lot better and that makes for a tight game. But that always seems to be the case in local derbies and it might be a penalty that decides the game."
GLOUCESTER (v Bath, tomorrow, Rec 2.45pm): Jon Goodridge; Mark Foster, Mike Tindall, Henry Paul, James Simpson-Daniel, Ludovic Mercier, Haydn Thomas; Patrice Collazo, Mefin Davies, Phil Vickery (capt), Adam Eustace, Alex Brown, Peter Buxton, Andy Hazell, James Forrester. Reps: James Parkes, Terry Sigley, Mark Cornwell, Jake Boer, Peter Richards, Terry Fanolua, Brad Davies.
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