The Kingsholm second row has sustained an injury to his neck and following advice from the Gloucester medical team he will not be considered for selection for forthcoming European Challenge Cup or Premiership matches.
Brown will continue to be monitored over the next seven days in case he makes any improvement but he will miss Gloucester's forthcoming fixtures as a result of the injury.
"Nothing else has been on my mind for the last few days and it is gutting to know I will miss an opportunity with Gloucester and potentially with England," Brown said.
"I will see a specialist and hopefully we will know more later this week. I just have to try and remain positive and take the best out of the situation and return fitter and stronger."
His head coach Dean Ryan added: "This is certainly unfortunate timing for Alex and for the club and his desire to play at an international level.
"He will be an obvious loss to us as we continue to evaluate his condition."
Brown signed for Gloucester in the summer of 2003 from Bristol. The A team international topped the line-out statistics during the 2003/4 season and was voted the players' player of the year.
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