Gloucester are set to name a strong side when they begin their Powergen Cup campaign against the Ospreys on Saturday (2.30pm).
Despite injuries to Duncan McRae and Jack Adams, Dean Ryan has no fresh concerns but may decide to leave out Phil Vickery, who has a shoulder injury, to give him more time to recover.
But he is expected to name a strong side tomorrow that could include James Forrester and Alex Brown, who were this week named in the England squad.
Adam Balding, Gloucester's skipper, said: "Gloucester are taking this competition very seriously because if you win there is a route into the Heineken Cup and that is where we want to be. For us to win this competition and get into Europe would be a fantastic achievement.
"Playing the Ospreys will be a tough opener. I don't know that much about their side but it is pretty obvious it is going to be a difficult game. We will be putting everything into training this week to make sure we keep our unbeaten record this season. We have had a good start to the season and we want to keep that momentum going."
Tickets are still available for the contest and the ticket office will remain open on Thursday night until 6.30pm to give supporters the chance to take advantage of the early purchase scheme, that allows £2 per purchase.
The ticket office will also be open on Saturday morning at 10am.
Speaking with the local media before the Gloucester team set off on the long trip north to Newcastle, Director of Rugby David Humphreys discussed his team selection and stated that Friday night's meeting will be a challenging one.
Speaking to the local media on Thursday, Matt Kvesic was looking forward to the trip to Newcastle Falcons, and the captain is looking to lead from the front with plenty for the Cherry and Whites to work on.
Gloucester saw a 12-0 lead overturned by Harlequins on Friday night as the visitors ran out 22-15 winners. After the game, Director of Rugby David Humphreys spoke about missed opportunities on the night.
Speaking to the local media on Thursday, James Hudson explained his excitement for tonight's game with Harlequins and that he is backing the Cherry and White squad to impress during the next set of Aviva Premiership games.
Despite a dream start at Kingston Park, scoring a try after just 26 seconds, Gloucester couldn't capitalise against a dogged Newcastle Falcons side. Too many penalties were conceded and too many errors made as the Falcons prevailed 20-10.
There are three changes to Gloucester Rugby's starting line-up for Friday evening's Aviva Premiership fixture away at Newcastle Falcons. Steve McColl will make his first Premiership start for the club.