A place in next season's Heineken Cup awaits the winners of the game, and Diamond makes two changes to his starting XV from the side that beat Worcester Warriors 28-10 in last week's semi-final.
Glen Jackson comes into the side at fly-half and the only other change sees Raphael Ibanez start at hooker with Matt Cairns named on the replacements bench.
Diamond said: "We know we have a huge job on our hands against Gloucester. Our forward pack came second best when we played them at Kingsholm a few weeks ago so we know the size of the task ahead of us.
"We will have to step up our performance levels on Saturday. The chance to compete in Europe next season is a big prize and one on which we are focussed."
Gloucester will announced their team after the final team run-through late morning on Friday.
Saracens team v Gloucester
15 Thomas Castaignede
14 Ben Johnston
13 Kevin Sorrell
12 Dan Harris
11 Tevita Vaikona
10 Glen Jackson
9 Moses Rauluni
1 Nick Lloyd
2 Raphael Ibanez
3 Cobus Visagie
4 Iain Fullarton
5 Simon Raiwalui
6 Ben Skirving
7 Richard Hill
8 Hugh Vyvyan (c)
16 Matt Cairns
17 Kevin Yates
18 Kris Chesney
19 Taine Randell
20 Kyran Bracken
21 Mark Bartholomeusz
22 Richard Haughton
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