Luke Narraway comes into the back row for Gloucester's Zurich Wild Card semi-final against Newcastle at Kingsholm on Sunday (Sun 8 May, Kingsholm, kick off 3.15pm - Tickets AVAILABLE).
The 21 year-old flanker replaces the injured Andy Hazell, who misses out after taking a knock to the head against Saracens last weekend.
Narraway started Gloucester's last clash with the Falcons at the end of February at Kingston Park and scored the team's fourth try in the 27-27 draw.
Seti Kiole returns to the wing after missing last Saturday's game through injury. He joins a reshuffled back three.
Jon Goodridge misses his first competitive fixture of the season with a shoulder injury that saw him go off after half an hour against Saracens, and Marcel Garvey is still absent with an elbow injury.
19 year-old England U21 Olly Morgan starts at full-back, with James Bailey staying on the wing after an impressive performance in last week's final league clash.
Director of rugby Nigel Melville and coach Dean Ryan have the final team run through on Saturday morning, when a few of the players will look to come through after a number of niggles caused disruption this week.
Jon Goodridge and Marcel Garvey are joined on the sidelines by Phil Vickery (broken arm), Mark Cornwell (neck), Chris Fortey (ankle), James Parkes (wrist) and Henry Paul (knee).
More than 5,200 tickets have been sold for the Wild Card semi-final, and supporters have until 5pm on Friday to take advantage of the 'early bird' discount. Tickets are available on-line at www.gloucesterrugbyclub.com, from the ticket hotline on 0871 871 8781 and from the ticket office at the ground.
Gloucester: 15. Olly Morgan
14. James Bailey
13. James Simpson-Daniel
12. Terry Fanolua
11. Seti Kiole
10. Duncan McRae
9. Andy Gomarsall
1. Nick Wood
2. Mefin Davies
3. Gary Powell
4. Adam Eustace
5. Alex Brown
6. Jake Boer
7. Luke Narraway
8. Adam Balding (c)
16. Olivier Azam
17. Terry Sigley
18. Peter Buxton
19. James Forrester
20. Alex Page
21. Brad Davies
22. Mark Foster
Speaking to the local media this week, John Afoa described the hard work that the Cherry and White have been putting in and that he is fighting fit ready for Saturday's European Rugby Challenge Cup semi final clash with Exeter Chiefs.
Gloucester Rugby face Exeter Chiefs this Saturday in the European Rugby Challenge Cup semi-final, and Charlie Sharples, who starts at full back is relishing the challenge of the big Kingsholm occasion.
Gloucester meet the Exeter Chiefs for the fourth time in competitive action this weekend, this time in the semi-final of the European Rugby Challenge Cup. Director of Rugby David Humphreys told the local media this week that this is the sort of game that Gloucester want to be involved in on a regular basis and that he and his team are looking forward to it.
Following the 29-26 loss to Harlequins, club captain Billy Twelvetrees spoke of his disappointment that the Cherry and Whites were unable to cash in on the home side's indiscipline and lose a lead on Saturday afternoon.
Number eight Gareth Evans admitted to a collective feeling of frustration as Gloucester lost narrowly at Harlequins on Saturday, but insisted that there are plenty of positives to draw upon ahead of next Saturday's European Rugby Challenge Cup semi-final at home to Exeter.
Gloucester travel to the Stoop on Saturday afternoon to take on Harlequins in the Aviva Premiership. The Cherry and Whites make just two changes from last weekend's win over Connacht as they seek consistency and continuity in their play as Nick Walshe told the local media this week.
Following Saturday evening's exciting European Rugby Challenge Cup semi-final victory over Exeter Chiefs, the Ticket Office at Kingsholm will be open on Sunday from 11am to 3pm for Club Members to purchase tickets for the Final.
Gloucester Rugby qualified for their first European final since 2006 as they defeated the in-form Exeter Chiefs by 30 points to 19 in a thrilling semi-final at Kingsholm on Saturday evening. The club photographer caught the best of the action.
Recent meetings between these two teams have often been thrillers, and this was no exception. It went down to the final few minutes, but Gloucester produced the goods when it mattered to qualify for the European Rugby Challenge Cup Final, beating Exeter 30-19.
Supporters who are still to purchase tickets for Saturday's European Rugby Challenge Cup semi-final at home to Exeter Chiefs at Kingsholm (kick off 7:45pm) are reminded that Early Bird prices are only valid until 6:30pm on Thursday evening.