Luke Narraway comes into the back row for Gloucester's Zurich Wild Card semi-final against Newcastle at Kingsholm on Sunday (Sun 8 May, Kingsholm, kick off 3.15pm - Tickets AVAILABLE).
The 21 year-old flanker replaces the injured Andy Hazell, who misses out after taking a knock to the head against Saracens last weekend.
Narraway started Gloucester's last clash with the Falcons at the end of February at Kingston Park and scored the team's fourth try in the 27-27 draw.
Seti Kiole returns to the wing after missing last Saturday's game through injury. He joins a reshuffled back three.
Jon Goodridge misses his first competitive fixture of the season with a shoulder injury that saw him go off after half an hour against Saracens, and Marcel Garvey is still absent with an elbow injury.
19 year-old England U21 Olly Morgan starts at full-back, with James Bailey staying on the wing after an impressive performance in last week's final league clash.
Director of rugby Nigel Melville and coach Dean Ryan have the final team run through on Saturday morning, when a few of the players will look to come through after a number of niggles caused disruption this week.
Jon Goodridge and Marcel Garvey are joined on the sidelines by Phil Vickery (broken arm), Mark Cornwell (neck), Chris Fortey (ankle), James Parkes (wrist) and Henry Paul (knee).
More than 5,200 tickets have been sold for the Wild Card semi-final, and supporters have until 5pm on Friday to take advantage of the 'early bird' discount. Tickets are available on-line at www.gloucesterrugbyclub.com, from the ticket hotline on 0871 871 8781 and from the ticket office at the ground.
Gloucester: 15. Olly Morgan
14. James Bailey
13. James Simpson-Daniel
12. Terry Fanolua
11. Seti Kiole
10. Duncan McRae
9. Andy Gomarsall
1. Nick Wood
2. Mefin Davies
3. Gary Powell
4. Adam Eustace
5. Alex Brown
6. Jake Boer
7. Luke Narraway
8. Adam Balding (c)
16. Olivier Azam
17. Terry Sigley
18. Peter Buxton
19. James Forrester
20. Alex Page
21. Brad Davies
22. Mark Foster
It's the first Gloucester-Bristol derby at Kingsholm in over eight years this Saturday (kick off 4:30pm) and, previewing the game with the local media this week, Defence Coach Jonny Bell stressed that, with both teams in the bottom half of the table, they both need the points.
Speaking to the local media this week, Gloucester front rower John Afoa knows the challenge ahead this week against Bristol, and calls on the Cherry and Whites to make the most of home advantage as a determined squad look to bounce back from a narrow loss to Saracens.
Tom Savage speaks to GRTV and the local media as Gloucester went down by 24-20 at Saracens on Sunday afternoon. The second row was disappointed with the result, despite a strong showing from the hosts.
Speaking immediately after the game, skipper Willi Heinz thought that Gloucester had executed their game plan reasonably well and competed hard against Saracens. However, it wasn't enough but the squad will have plenty to work on this week ahead of the derby match against Bristol.
Gloucester may be coming off their best win of the season, the 38-16 victory over Wasps last weekend, but Director of Rugby David Humphreys admits that Sunday's trip to Saracens is an even tougher test.
After a series of contract announcements last week, hooker Richard Hibbard is the latest Gloucester Rugby player to commit to a new contract at the club and told GRTV how much he enjoys playing in the Cherry and White of Gloucester.
A try scorer in the 36-18 Aviva Premiership win over Wasps at Kingsholm on Saturday, Charlie Sharples admitted that Gloucester would enjoy the moment but can't get too carried away. The team got what they deserved but the winger wants these performances to be more frequent.
England Head Coach Eddie Jones has made two changes to his side to play Australia in Saturday's final match of the Old Mutual Wealth Series at Twickenham Stadium (kick-off 2.30pm, live on Sky Sports 2). Jonny May lines up on the left wing.