Luke Narraway comes into the back row for Gloucester's Zurich Wild Card semi-final against Newcastle at Kingsholm on Sunday (Sun 8 May, Kingsholm, kick off 3.15pm - Tickets AVAILABLE).
The 21 year-old flanker replaces the injured Andy Hazell, who misses out after taking a knock to the head against Saracens last weekend.
Narraway started Gloucester's last clash with the Falcons at the end of February at Kingston Park and scored the team's fourth try in the 27-27 draw.
Seti Kiole returns to the wing after missing last Saturday's game through injury. He joins a reshuffled back three.
Jon Goodridge misses his first competitive fixture of the season with a shoulder injury that saw him go off after half an hour against Saracens, and Marcel Garvey is still absent with an elbow injury.
19 year-old England U21 Olly Morgan starts at full-back, with James Bailey staying on the wing after an impressive performance in last week's final league clash.
Director of rugby Nigel Melville and coach Dean Ryan have the final team run through on Saturday morning, when a few of the players will look to come through after a number of niggles caused disruption this week.
Jon Goodridge and Marcel Garvey are joined on the sidelines by Phil Vickery (broken arm), Mark Cornwell (neck), Chris Fortey (ankle), James Parkes (wrist) and Henry Paul (knee).
More than 5,200 tickets have been sold for the Wild Card semi-final, and supporters have until 5pm on Friday to take advantage of the 'early bird' discount. Tickets are available on-line at www.gloucesterrugbyclub.com, from the ticket hotline on 0871 871 8781 and from the ticket office at the ground.
Gloucester: 15. Olly Morgan
14. James Bailey
13. James Simpson-Daniel
12. Terry Fanolua
11. Seti Kiole
10. Duncan McRae
9. Andy Gomarsall
1. Nick Wood
2. Mefin Davies
3. Gary Powell
4. Adam Eustace
5. Alex Brown
6. Jake Boer
7. Luke Narraway
8. Adam Balding (c)
16. Olivier Azam
17. Terry Sigley
18. Peter Buxton
19. James Forrester
20. Alex Page
21. Brad Davies
22. Mark Foster
Speaking after he kicked 20 points in Gloucester's 25-15 win over Oyonnax on Saturday evening, Greig Laidlaw admitted that the game had been every bit as challenging as expected and praised the massive effort put in by the pack.
Speaking after the 25-15 European Rugby Challenge Cup win in France, David Humphreys told the local media that he was delighted that his Gloucester team matched Oyonnax's intensity on the night and made it two wins from two in Europe.
Gloucester travel to Oyonnax for the second round of the European Rugby Challenge Cup on Saturday evening, and Director of Rugby David Humphreys is expecting a big test from the French side, feeling that their league position doesn't reflect their recent performances.
Speaking exclusively to Gloucester Rugby TV, Matt Kvesic explained that his decision to extend his contract at Kingsholm was a simple one and that he was hugely excited for the future in Cherry and White.
Speaking after the 55-0 win over CA Brive, Jonny May told GRTV that he's delighted that the team's hard work is starting to pay dividends but was equally happy for his friend and team mate, Charlie Sharples, on what was a big night for his fellow winger.
The start of the 2014/2015 LV= Cup season launched exclusively on social media today with players from the 16 English and Welsh participating clubs tweeting team 'selfies' to kick-off the new campaign.