Luke Narraway comes into the back row for Gloucester's Zurich Wild Card semi-final against Newcastle at Kingsholm on Sunday (Sun 8 May, Kingsholm, kick off 3.15pm - Tickets AVAILABLE).
The 21 year-old flanker replaces the injured Andy Hazell, who misses out after taking a knock to the head against Saracens last weekend.
Narraway started Gloucester's last clash with the Falcons at the end of February at Kingston Park and scored the team's fourth try in the 27-27 draw.
Seti Kiole returns to the wing after missing last Saturday's game through injury. He joins a reshuffled back three.
Jon Goodridge misses his first competitive fixture of the season with a shoulder injury that saw him go off after half an hour against Saracens, and Marcel Garvey is still absent with an elbow injury.
19 year-old England U21 Olly Morgan starts at full-back, with James Bailey staying on the wing after an impressive performance in last week's final league clash.
Director of rugby Nigel Melville and coach Dean Ryan have the final team run through on Saturday morning, when a few of the players will look to come through after a number of niggles caused disruption this week.
Jon Goodridge and Marcel Garvey are joined on the sidelines by Phil Vickery (broken arm), Mark Cornwell (neck), Chris Fortey (ankle), James Parkes (wrist) and Henry Paul (knee).
More than 5,200 tickets have been sold for the Wild Card semi-final, and supporters have until 5pm on Friday to take advantage of the 'early bird' discount. Tickets are available on-line at www.gloucesterrugbyclub.com, from the ticket hotline on 0871 871 8781 and from the ticket office at the ground.
Gloucester: 15. Olly Morgan
14. James Bailey
13. James Simpson-Daniel
12. Terry Fanolua
11. Seti Kiole
10. Duncan McRae
9. Andy Gomarsall
1. Nick Wood
2. Mefin Davies
3. Gary Powell
4. Adam Eustace
5. Alex Brown
6. Jake Boer
7. Luke Narraway
8. Adam Balding (c)
16. Olivier Azam
17. Terry Sigley
18. Peter Buxton
19. James Forrester
20. Alex Page
21. Brad Davies
22. Mark Foster
Speaking to the local media this week, David Humphreys insisted that Gloucester are looking forward to kicking off the new European Rugby Challenge Cup against Brive on Thursday evening, although an unfamiliar opponent and a five day turnaround will pose a challenge.
Director of Rugby David Humphreys felt that his Gloucester side put themselves in a position to put Saracens under real pressure at Allianz Park on Saturday, praising his team's commitment and defence, while admitting that a lack of accuracy hit their chances in the second half.
Speaking to the local media at Allianz Park, Tom Savage was disappointed after the defeat at Saracens, but claimed Gloucester did plenty of good things and could've taken more than a losing bonus point.
In case you missed it, there was plenty of activity on the official Gloucester Rugby website following the 55-0 European Rugby Challenge Cup win over CA Brive, including a number of post match video interviews.
The Cherry and Whites ran in seven tries in beating CA Brive 55-0 on Thursday night. An emphatic second half performance saw the hosts run in five tries to get the European campaign off to a flying start.