The Kingsholm coach has made only five changes to the side that won 74-3 in France last Saturday night for the return encounter tomorrow - and is able to welcome back England centre James Simpson-Daniel.
He has missed the last two matches because of a hip injury picked up on international duty against Samoa last month and is one of two three changes in the backline.
Rob Thirlby replaces Marcel Garvey on the wing and Jon Goodridge comes into the side at full-back in place of Olly Morgan.
In the pack, Ryan has changed both his props. Nick Wood comes in at loosehead in place of Patrice Collazo and Gary Powell replaces Phil Vickery.
Vickery is rested and not included this weekend, which means Jack Forster, the England Under-19 prop from Hartpury College, comes into the senior squad for the first time.
Adam Balding takes the captaincy armband as Gloucester aim for a fourth successive European victory.
"To simply think we can replicate what happened in France last weekend would be highly disrespectful to Toulon but what we have to ensure is that get our preparation right," Ryan told www.gloucesterrugby.co.uk
"If we concentrate on getting everything right ourselves, hopefully the scoreboard will take of itself. During the autumn international period we lost some of the momentum we built up and we now have to re-discover it.
"Tomorrow is a major step towards that so there will be no let up in terms of our intensity or approach. We are working exceptionally hard as a group and that must continue."
Jonathan Pendlebury retains his place in the second row alongside Alex Brown following his outstanding contribution last weekend and the back row also remains intact with Peter Buxton on the bench.
But the return of Simpson-Daniel from injury is a major bonus with two Guinness Premiership matches over Christmas against Wasps and Leeds.
"To have someone of James's ability back involved is a huge bonus for us," Ryan said. "He brings a creativity and a level of footballing skill that any team would delighted to have.
"We have two very important matches over the Christmas period and we obviously want him involved in those."
On the bench, Adam Eustace returns in place of Quinton Davids, who played in a United fixture against Leicester on Monday, while Terry Fanolua drops down because of Simpson-Daniel's return.
Olly Morgan and Anthony Allen are both rested.
"We did a professional job last weekend and we need to build on that tomorrow," Ryan added. "Nothing is taken for granted - we have to produce a good performance and build our momentum."
GLOUCESTER RUGBY (v Toulon, Tomorrow, Kingsholm 3pm): Jon Goodridge; Rob Thirlby, James Simpson-Daniel, Mike Tindall; Mark Foster; Ludovic Mercier, Peter Richards; Nick Wood, Mefin Davies, Gary Powell, Jonathan Pendlebury, Alex Brown, Adam Balding (capt), Jake Boer, James Forrester. Reps: Rob Elloway, Jack Forster, Adam Eustace, Peter Buxton, Duncan McRae, Haydn Thomas, Terry Fanolua.
There are still tickets available for tomorrow's encounter and the ticket office will open at 9am on Saturday, they are available from the hotline number 0871 871 8781 or online at www.gloucesterrugby.co.uk.
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