MIKE TINDALL underwent surgery on Saturday evening to have a pin inserted into the lower third of the tibia in his right leg following his fracture against Newcastle Falcons on Friday.
The Gloucester and England star suffered the undisplaced fracture in the second half of Gloucester's 19-12 defeat at Kingston Park and faces a minimum of 12 weeks' recovery time.
"An injury of this severity to one of our key individuals at this stage of the season is obviously a serious blow because Mike possesses all the characteristics you require during the play-offs," head coach Dean Ryan told www.gloucesterrugby.co.uk
"He has big-game experience, natural leadership qualities and knows what it takes to win these one-off matches and we will miss his contribution."
Gloucester can also confirm that Karl Pryce faces a lengthy spell on the sidelines. The former rugby league winger re-fractured a bone in his left foot during his Guinness Premiership debut against Northampton last month and has had a pin inserted.
The 20-year-old will now focus on rehabilitation over the summer with a view to returning to first team action at the start of next season.
"We wish Mike and Karl all the very best in their recovery processes and will be right behind them," added Ryan.
Gloucester recorded a 32-20 win over La Rochelle on Thursday evening, and second row Jeremy Thrush was thrilled to pick up the victory on his first taste of a trip to France and the hostile atmosphere.
Gloucester were forced to battle for their 33-20 victory in La Rochelle on Thursday evening, something that centre Bill Meakes said that he and the squad were well prepared for as well as thanking the travelling support for the part they played.
Gloucester got off to a winning start in the European Rugby Challenge Cup last weekend, but Head Coach Laurie Fisher is expecting a much tougher challenge when the Cherry and Whites travel to La Rochelle for Thursday night's Round Two encounter.
Dan Thomas was a try scorer in the 14-62 defeat at the hands of the Barbarians on Tuesday evening, but told GRTV after the game that he'd really enjoyed taking on the Barbarians and locking horns with Ardie Savea at the breakdown.
After a long, hard battle to return to fitness, Henry Trinder made his long awaited comeback in the second half of the 23-10 win over Zebre on Saturday and admitted he was taken aback by the reception he got from the Kingsholm crowd.
21 year old number eight Lewis Ludlow formed part of a physical back row effort in the 23-10 European Rugby Challenge Cup over Zebre on Saturday. Speaking to GRTV after the game, he spoke of making the most of his chances and being happy to contribute to the Gloucester win.
Gloucester United kick off their Aviva Premiership A League campaign against Leicester Tigers at Welford Road on Monday evening (kick off 7pm) and have named a side which features lots of first team experience.