MIKE TINDALL underwent surgery on Saturday evening to have a pin inserted into the lower third of the tibia in his right leg following his fracture against Newcastle Falcons on Friday.
The Gloucester and England star suffered the undisplaced fracture in the second half of Gloucester's 19-12 defeat at Kingston Park and faces a minimum of 12 weeks' recovery time.
"An injury of this severity to one of our key individuals at this stage of the season is obviously a serious blow because Mike possesses all the characteristics you require during the play-offs," head coach Dean Ryan told www.gloucesterrugby.co.uk
"He has big-game experience, natural leadership qualities and knows what it takes to win these one-off matches and we will miss his contribution."
Gloucester can also confirm that Karl Pryce faces a lengthy spell on the sidelines. The former rugby league winger re-fractured a bone in his left foot during his Guinness Premiership debut against Northampton last month and has had a pin inserted.
The 20-year-old will now focus on rehabilitation over the summer with a view to returning to first team action at the start of next season.
"We wish Mike and Karl all the very best in their recovery processes and will be right behind them," added Ryan.
As Gloucester prepare for their 39th game of the season, against Bordeaux-Begles at Sixways on Sunday, David Humphreys told the local media that this week has been all about getting the players mentally and physically ready after a tough game against Connacht last Sunday.
Speaking to GRTV after the 40-32 victory over Connacht on Sunday, skipper Billy Twelvetrees explained that Gloucester had had to learn to be patient and cut out the errors to earn the win and progress to next weekend's final play-off against Bordeaux-Begles.
Jonny May's superb late score capped a thrilling 40-32 European play-off win over Connacht on Sunday. The winger spoke afterwards of his team's character and spirit as he looked ahead to one more week of rugby.
Speaking to GRTV this afternoon, Director of Rugby David Humphreys hailed the 'never say die' attitude of the team, after despite not being at their best, fighting back to take a 40-32 win after extra time over Connacht.
Jonny May continues on the wing on Sunday as Connacht come to town, and the England wing explains to the local media this week that he is delighted with his form and is looking forward to taking on Pat Lam's men.
Speaking to Russ Hargreaves of Talking Rugby at Friday's launch of the Aviva Premiership Rugby and Singha 7s fixtures, Henry Trinder discussed the early stages of preseason and the campaign that lies ahead.
Premiership Rugby have this morning confirmed the order of fixtures for the 2015/16 season, and Gloucester Rugby will start their campaign at Kingston Park, taking on Newcastle Falcons on Friday 16 October, 19:45.