HOOKER Andy Titterrell will make his first Guinness Premiership start for Gloucester against Saracens on Sunday (3pm).
The former Sale man will be joined in the front row by Nick Wood as head coach Dean Ryan shuffles his forward pack for Gloucester's second successive away game.
Wood did not feature during Gloucester's 49-24 victory over Leeds Carnegie last Sunday but comes in for Patrice Collazo, while Titterrell starts in place of Olivier Azam, who moves to the bench.
"I don't think it's hard to make changes in this squad," said head coach Ryan. "We recognise the group is more than 15 players and the quality of the group is more than 15 players which is very important to us.
"The season is nine months long we will make changes which aren't necessarily on selection and form but are when there are people as good to come into the position.
"It's important to keep people hungry and keep pressure on - I thought Andy was very impressive when he came off the bench last weekend and we know of Nick's qualities as an emerging prop who was good enough to earn selection to an England squad last season.
"We have picked a team we feel is right for this game and this environment and we are happy with the options."
The only other change is in the second row where Peter Buxton replaces Jonathan Pendlebury at number four meaning Alasdair Strokosch comes in on the flank.
"As a group I think we appreciate what was on offer last weekend will not be there on Sunday and I think Alan Gaffney [Saracens' director of rugby] deserves a lot of credit for what he has already achieved there.
"They play at high speed, will try and create pressure and have a very good group of players. This will be a significant away game for us."
Wood and Titterrell will be joined in the front row with Carlos Nieto, while Buxton will partner Alex Brown at lock. Strokosch comes in on the blindside flank and will partner Andy Hazell and Luke Narraway at number eight.
The backs remain the same which means Lesley Vainikolo, who scored a debut record five tries against Leeds, will play his second Premiership match in a back three alongside James Simpson-Daniel and Iain Balshaw.
Leon Lloyd and Anthony Allen are the centre combination with Ryan Lamb and Mike Prendergast at half-back.
On the bench, Adam Balding returns to the squad in place of Dan Tuohy and Pendlebury makes a straight swap with Strokosch. Azam and Christian Califano are the front row replacements.
Scrum-half Dave Lewis, utility back Willie Walker and full-back Olly Morgan are the three-quarter options. Walker returns after suffered a dead leg in last Friday's team run. Please note that James Bailey is travelling with the squad.
GLOUCESTER (v Saracens, Sunday, September 23 3pm): Iain Balshaw; James Simpson-Daniel, Leon Lloyd, Anthony Allen, Lesley Vainikolo; Ryan Lamb, Mike Prendergast; Nick Wood, Andy Titterrell, Carlos Nieto, Peter Buxton (capt), Alex Brown, Alasdair Strokosch, Andy Hazell, Luke Narraway. Reps: Olivier Azam, Christian Califano, Jonathan Pendlebury, Adam Balding, Dave Lewis, Willie Walker, Olly Morgan.
Speaking to the media after the 45-8 preseason friendly victory over Munster, Director of Rugby David Humphreys wasn't getting too carried away, admitting that his team are making progress but that there's still a way to go.
Billy Twelvetrees spoke to Gloucester Rugby TV on Friday ahead of the pre season friendly with Munster Rugby. The club captain is excited to be back in the action at Kingsholm and experience the atmosphere again.
Gloucester Rugby Director of Rugby David Humphreys spoke to the local media after the 62-19 victory over Yorkshire Carnegie, and showed his delight at the first run out and stated there was still lots to work on ahead of the new season
Mark Atkinson made his first appearance in Cherry and White in the pre season victory over Yorkshire Carnegie on Saturday. Speaking to the local media, he was impressed with the first experience of Kingsholm.
James Hook picked himself up a pair of tries on his first appearance in Cherry and Whites during the 62-19 win over Yorkshire Carnegie. Speaking to the media after, the Welshman was thrilled with the first run out as well as the result.
England Rugby 2015, the Organising Committee for Rugby World Cup 2015 (RWC 2015), has announced the list of 41 Team Bases which will host the 20 participating teams during the Tournament, taking place in England and in Cardiff between September 18 and October 31 2015.
With the Gloucestershire weather taking a turn for the worst on Bank Holiday Monday, the club's Open Day will still be going ahead despite the rain, and Gloucester Rugby are looking forward to welcoming you to Kingsholm.