HOOKER Andy Titterrell will make his first Guinness Premiership start for Gloucester against Saracens on Sunday (3pm).
The former Sale man will be joined in the front row by Nick Wood as head coach Dean Ryan shuffles his forward pack for Gloucester's second successive away game.
Wood did not feature during Gloucester's 49-24 victory over Leeds Carnegie last Sunday but comes in for Patrice Collazo, while Titterrell starts in place of Olivier Azam, who moves to the bench.
"I don't think it's hard to make changes in this squad," said head coach Ryan. "We recognise the group is more than 15 players and the quality of the group is more than 15 players which is very important to us.
"The season is nine months long we will make changes which aren't necessarily on selection and form but are when there are people as good to come into the position.
"It's important to keep people hungry and keep pressure on - I thought Andy was very impressive when he came off the bench last weekend and we know of Nick's qualities as an emerging prop who was good enough to earn selection to an England squad last season.
"We have picked a team we feel is right for this game and this environment and we are happy with the options."
The only other change is in the second row where Peter Buxton replaces Jonathan Pendlebury at number four meaning Alasdair Strokosch comes in on the flank.
"As a group I think we appreciate what was on offer last weekend will not be there on Sunday and I think Alan Gaffney [Saracens' director of rugby] deserves a lot of credit for what he has already achieved there.
"They play at high speed, will try and create pressure and have a very good group of players. This will be a significant away game for us."
Wood and Titterrell will be joined in the front row with Carlos Nieto, while Buxton will partner Alex Brown at lock. Strokosch comes in on the blindside flank and will partner Andy Hazell and Luke Narraway at number eight.
The backs remain the same which means Lesley Vainikolo, who scored a debut record five tries against Leeds, will play his second Premiership match in a back three alongside James Simpson-Daniel and Iain Balshaw.
Leon Lloyd and Anthony Allen are the centre combination with Ryan Lamb and Mike Prendergast at half-back.
On the bench, Adam Balding returns to the squad in place of Dan Tuohy and Pendlebury makes a straight swap with Strokosch. Azam and Christian Califano are the front row replacements.
Scrum-half Dave Lewis, utility back Willie Walker and full-back Olly Morgan are the three-quarter options. Walker returns after suffered a dead leg in last Friday's team run. Please note that James Bailey is travelling with the squad.
GLOUCESTER (v Saracens, Sunday, September 23 3pm): Iain Balshaw; James Simpson-Daniel, Leon Lloyd, Anthony Allen, Lesley Vainikolo; Ryan Lamb, Mike Prendergast; Nick Wood, Andy Titterrell, Carlos Nieto, Peter Buxton (capt), Alex Brown, Alasdair Strokosch, Andy Hazell, Luke Narraway. Reps: Olivier Azam, Christian Califano, Jonathan Pendlebury, Adam Balding, Dave Lewis, Willie Walker, Olly Morgan.
Tom Marshall scored his first Gloucester try in the 31-23 win over Saracens on Friday evening and was named Man of the Match. Talking to GRTV, he praised the forwards for setting the tone on the night.
Matt Scott was on media duty this week, and the Scottish international spoke about the benefit of having a full week of training with his club mates and the determination to get back to performing well against Saracens this Friday evening.
After the disappointment of last weekend's performance at Leicester, Director of Rugby David Humphreys told GRTV that he expects a big response from Gloucester in Friday's Aviva Premiership fixture at home to Saracens (kick off 7:45pm).
Gloucester travel to Tigers this Saturday in good spirits, and fly half Billy Burns is looking forward to testing himself in one of the toughest environments in the league as the Cherry and White hunt vital points as attention returns to the Aviva Premiership
Gloucester's Ciaran Knight made his first start at tighthead prop, Henry Walker made his first appearance as a second half replacement and Alex Seville also featured as England U20s might it three from three in the U20s Six Nations with a 46-0 win over Italy in Darlington on Friday night.
Mental health and wellbeing is just as important as physical health, which is why the Gloucester Rugby Community team have partnered with Public Health Gloucestershire to become Mental Health First Aiders.