HOOKER Andy Titterrell will make his first Guinness Premiership start for Gloucester against Saracens on Sunday (3pm).
The former Sale man will be joined in the front row by Nick Wood as head coach Dean Ryan shuffles his forward pack for Gloucester's second successive away game.
Wood did not feature during Gloucester's 49-24 victory over Leeds Carnegie last Sunday but comes in for Patrice Collazo, while Titterrell starts in place of Olivier Azam, who moves to the bench.
"I don't think it's hard to make changes in this squad," said head coach Ryan. "We recognise the group is more than 15 players and the quality of the group is more than 15 players which is very important to us.
"The season is nine months long we will make changes which aren't necessarily on selection and form but are when there are people as good to come into the position.
"It's important to keep people hungry and keep pressure on - I thought Andy was very impressive when he came off the bench last weekend and we know of Nick's qualities as an emerging prop who was good enough to earn selection to an England squad last season.
"We have picked a team we feel is right for this game and this environment and we are happy with the options."
The only other change is in the second row where Peter Buxton replaces Jonathan Pendlebury at number four meaning Alasdair Strokosch comes in on the flank.
"As a group I think we appreciate what was on offer last weekend will not be there on Sunday and I think Alan Gaffney [Saracens' director of rugby] deserves a lot of credit for what he has already achieved there.
"They play at high speed, will try and create pressure and have a very good group of players. This will be a significant away game for us."
Wood and Titterrell will be joined in the front row with Carlos Nieto, while Buxton will partner Alex Brown at lock. Strokosch comes in on the blindside flank and will partner Andy Hazell and Luke Narraway at number eight.
The backs remain the same which means Lesley Vainikolo, who scored a debut record five tries against Leeds, will play his second Premiership match in a back three alongside James Simpson-Daniel and Iain Balshaw.
Leon Lloyd and Anthony Allen are the centre combination with Ryan Lamb and Mike Prendergast at half-back.
On the bench, Adam Balding returns to the squad in place of Dan Tuohy and Pendlebury makes a straight swap with Strokosch. Azam and Christian Califano are the front row replacements.
Scrum-half Dave Lewis, utility back Willie Walker and full-back Olly Morgan are the three-quarter options. Walker returns after suffered a dead leg in last Friday's team run. Please note that James Bailey is travelling with the squad.
GLOUCESTER (v Saracens, Sunday, September 23 3pm): Iain Balshaw; James Simpson-Daniel, Leon Lloyd, Anthony Allen, Lesley Vainikolo; Ryan Lamb, Mike Prendergast; Nick Wood, Andy Titterrell, Carlos Nieto, Peter Buxton (capt), Alex Brown, Alasdair Strokosch, Andy Hazell, Luke Narraway. Reps: Olivier Azam, Christian Califano, Jonathan Pendlebury, Adam Balding, Dave Lewis, Willie Walker, Olly Morgan.
Argentine international Mariano Galarza made his Gloucester Rugby debut on Sunday afternoon, and despite a disappointing reverse to Sale Sharks, the giant Puma was just glad to be making his long-awaited bow in Cherry and White.
Having skippered Scotland to a hard fought 25-13 defeat against England at Twickenham on Saturday, Greig Laidlaw spoke of the frustrations of his side doing so many good things and making real progress as a team but still finishing on the wrong end of the scoreline.
GRTV caught up with Neil McCarthy as he was unveiled as the new Head of Academy. The ex-Gloucester front rower is looking forward to getting to work with the vast arrays of talent in the Academy and across Gloucestershire.
Although understandably disappointed to see Northampton snatch a 33-33 draw with a last gasp try on Saturday, Gareth Evans told GRTV after the game that the result shows how far Gloucester have come as a team this season.
Gloucester scrum half Greig Laidlaw spoke to GRTV after the 33-33 draw with Northampton Saints on Saturday, and the Scotsman described how the hosts played some great rugby, but will rue not holding the lead which keeps them in touch with the top seven.
Although Gloucester could take many positives from the 33-33 draw with Northampton Saints on Saturday, centre Bill Meakes admitted it was a strange feeling at the final whistle with Gloucester having probably done enough to win the game.
Speaking after the 33-33 draw with Northampton Saints on Saturday, David Humphreys admitted that he was happy with many aspects of the team's performance but regretted a missed opportunity to defeat the Premiership champions.
Hartpury U18s won the AASE league for the sixth year in a row last week beating Filton College in the Final at Allianz Park by 50 points to nil, while Bromsgrove School won their first NatWest U18 Schools Cup.
Gloucester Rugby would like to inform supporters about an exciting opportunity for you to raise money for your chosen charity or chosen cause. 2015 is an exciting year for Gloucester, with Kingsholm Stadium hosting four fixtures for Rugby World Cup 2015.