HOOKER Andy Titterrell will make his first Guinness Premiership start for Gloucester against Saracens on Sunday (3pm).
The former Sale man will be joined in the front row by Nick Wood as head coach Dean Ryan shuffles his forward pack for Gloucester's second successive away game.
Wood did not feature during Gloucester's 49-24 victory over Leeds Carnegie last Sunday but comes in for Patrice Collazo, while Titterrell starts in place of Olivier Azam, who moves to the bench.
"I don't think it's hard to make changes in this squad," said head coach Ryan. "We recognise the group is more than 15 players and the quality of the group is more than 15 players which is very important to us.
"The season is nine months long we will make changes which aren't necessarily on selection and form but are when there are people as good to come into the position.
"It's important to keep people hungry and keep pressure on - I thought Andy was very impressive when he came off the bench last weekend and we know of Nick's qualities as an emerging prop who was good enough to earn selection to an England squad last season.
"We have picked a team we feel is right for this game and this environment and we are happy with the options."
The only other change is in the second row where Peter Buxton replaces Jonathan Pendlebury at number four meaning Alasdair Strokosch comes in on the flank.
"As a group I think we appreciate what was on offer last weekend will not be there on Sunday and I think Alan Gaffney [Saracens' director of rugby] deserves a lot of credit for what he has already achieved there.
"They play at high speed, will try and create pressure and have a very good group of players. This will be a significant away game for us."
Wood and Titterrell will be joined in the front row with Carlos Nieto, while Buxton will partner Alex Brown at lock. Strokosch comes in on the blindside flank and will partner Andy Hazell and Luke Narraway at number eight.
The backs remain the same which means Lesley Vainikolo, who scored a debut record five tries against Leeds, will play his second Premiership match in a back three alongside James Simpson-Daniel and Iain Balshaw.
Leon Lloyd and Anthony Allen are the centre combination with Ryan Lamb and Mike Prendergast at half-back.
On the bench, Adam Balding returns to the squad in place of Dan Tuohy and Pendlebury makes a straight swap with Strokosch. Azam and Christian Califano are the front row replacements.
Scrum-half Dave Lewis, utility back Willie Walker and full-back Olly Morgan are the three-quarter options. Walker returns after suffered a dead leg in last Friday's team run. Please note that James Bailey is travelling with the squad.
GLOUCESTER (v Saracens, Sunday, September 23 3pm): Iain Balshaw; James Simpson-Daniel, Leon Lloyd, Anthony Allen, Lesley Vainikolo; Ryan Lamb, Mike Prendergast; Nick Wood, Andy Titterrell, Carlos Nieto, Peter Buxton (capt), Alex Brown, Alasdair Strokosch, Andy Hazell, Luke Narraway. Reps: Olivier Azam, Christian Califano, Jonathan Pendlebury, Adam Balding, Dave Lewis, Willie Walker, Olly Morgan.
Gloucester Rugby face Exeter Chiefs this Saturday in the European Rugby Challenge Cup semi-final, and Charlie Sharples, who starts at full back is relishing the challenge of the big Kingsholm occasion.
Gloucester meet the Exeter Chiefs for the fourth time in competitive action this weekend, this time in the semi-final of the European Rugby Challenge Cup. Director of Rugby David Humphreys told the local media this week that this is the sort of game that Gloucester want to be involved in on a regular basis and that he and his team are looking forward to it.
Following the 29-26 loss to Harlequins, club captain Billy Twelvetrees spoke of his disappointment that the Cherry and Whites were unable to cash in on the home side's indiscipline and lose a lead on Saturday afternoon.
Number eight Gareth Evans admitted to a collective feeling of frustration as Gloucester lost narrowly at Harlequins on Saturday, but insisted that there are plenty of positives to draw upon ahead of next Saturday's European Rugby Challenge Cup semi-final at home to Exeter.
Gloucester travel to the Stoop on Saturday afternoon to take on Harlequins in the Aviva Premiership. The Cherry and Whites make just two changes from last weekend's win over Connacht as they seek consistency and continuity in their play as Nick Walshe told the local media this week.
Supporters who are still to purchase tickets for Saturday's European Rugby Challenge Cup semi-final at home to Exeter Chiefs at Kingsholm (kick off 7:45pm) are reminded that Early Bird prices are only valid until 6:30pm on Thursday evening.
The Gloucester Wheelchair Rugby team travelled to Fenton Manor Complex, Stoke on Trent last Saturday to take part in the final round of the GBWR Super Series of the season, knowing just one win would be enough to crown them Division 3 Champions.