Boer is ruled out with strained ligaments in his knee and his loss will be considerable blow, particularly after his try-scoring effort in Gloucester's 35-13 victory over Bristol last Saturday.
Head coach Dean Ryan is also without James Forrester, who ruptured his ACL joint at Ashton Gate - but the rest of the starting line-up remains unchanged.
"The severity of James Forrester's injury was confirmed on Monday and to lose a player of Jake's quality too is obviously a blow to us at this stage," Ryan told www.gloucesterrugby.co.uk
"I thought Jake was outstanding last weekend - he is a hugely respected guy in our squad - but Luke Narraway is also a very good player, has gained plenty of experience this season and will bring athleticism, determination and effort to our side."
Narraway has made 16 appearances in all competitions this season and will partner Andy Hazell and Peter Buxton in the back row - two men who were named in England's tour squad to South Africa this week.
The rest of the pack is unchanged which means Marco Bortolami skippers the side from the second row alongside Alex Brown.
It will be Bortolami's 22nd appearance in all competitions tomorrow and in front of him will be loose-head prop Nick Wood, hooker Olivier Azam and tight-head prop Carlos Nieto.
Gloucester's three-quarter line also has a settled look and will see Peter Richards partner Ryan Lamb at half-back. Lamb has scored 82 points in 16 Premiership appearances this season and is the second leading point's scorer behind Willie Walker.
The centre combination of Anthony Allen and James Simpson-Daniel is intact because of the fractured leg to Mike Tindall, while Walker, Mark Foster and Iain Balshaw complete the back three. James Bailey is ruled out with a groin strain.
"For me, it is about getting our performance right," Ryan added. "We have not talked about semi-finals or finals because when you start tagging emotional issues like that onto what you are trying to achieve, you lose sight of playing well and that is the most important thing.
"We have talked about the second half at Bath and the game at Newcastle and know we cannot repeat them. We are back at Kingsholm, which is also a very special place for us, and are solely concentrating on getting our game right.
"Ashton Gate was a great experience for everyone but Kingsholm's matchday atmosphere is pretty unique and we will need that tomorrow."
On the bench, Adam Eustace comes in because of Narraway's inclusion but the rest remain the same which means Mefin Davies and Christian Califano are the front row replacements, while Will James and Eustace cover lock and back row.
Rory Lawson, Jack Adams and Jon Goodridge are the three-quarter replacements
GLOUCESTER v Saracens (tomorrow, 1pm): Willie Walker, Mark Foster, James Simpson-Daniel, Anthony Allen, Iain Balshaw; Ryan Lamb, Peter Richards, Nick Wood, Olivier Azam, Carlos Nieto, Marco Bortolami (capt), Alex Brown, Peter Buxton, Andy Hazell, Luke Narraway. Reps: Mefin Davies, Christian Califano, Will James, Adam Eustace, Rory Lawson, Jack Adams, Jon Goodridge.
There are still limited tickets available for tomorrow and they are available from the hotline number on 0871 871 8781 or www.gloucesterrugby.co.uk
The ticket office will not be open tomorrow to buy tickets because the compound is being used as a team changing area.
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