"After this weekend we will have our internationals back and available for the run-in towards the end of the season and having James around is also a mighty boost," head coach Dean Ryan told www.gloucesterrugby.co.uk
"We saw last week that in the dry conditions there is more movement to our game and that suits the way James operates perfectly. Hopefully, if conditions stay the same, he can have an influence on what we are trying to achieve.
"He is an international-quality player who has plenty of experience so to have him fit at this stage is great news."
In his nine Guinness Premiership appearances this season Forrester has scored three times.
Away from the forwards, Ryan has been forced into one other change from the side that beat Leicester 28-24 last Sunday. Iain Balshaw is ruled out with a groin injury which means Mark Foster returns to the wing.
"We are aware that if we can achieve a good result in front of our own supporters then we would be in a good position to push on until the end of the season," Ryan added.
"I think there is plenty more to come from this side but we are developing in the right way and that is what pleases me."
Despite the absence of Italian internationals Marco Bortolami and Carlos Nieto, Gloucester's forwards have a settled feel. Nick Wood, Olivier Azam and Jack Forster form the front row, Will James and Alex Brown are second row combinations, while Peter Buxton, Andy Hazell and Forrester are the back row.
Buxton has featured in all but one of Gloucester's Premiership games so far this season and will make his 18 league appearance and it will be his 25th appearance in all competitions.
In the backs, Willie Walker, who kicked 18 points against Leicester, keeps the number 15 shirt, James Simpson-Daniel and Anthony Allen start in the centre and James Bailey and Foster are the wings. Peter Richards and Ryan Lamb are the half-backs.
On the bench, Ryan has opted for a four-three forward split. Mefin Davies and Patrice Collazo will cover the forward options, while Adam Eustace and Jonathan Pendlebury complete the options.
Haydn Thomas, Jon Goodridge and Rudi Keil are the three-quarter options.
GLOUCESTER (V Harlequins, tomorrow, 3pm): Willie Walker; James Bailey, James Simpson-Daniel, Anthony Allen, Mark Foster; Ryan Lamb, Peter Richards, Nick Wood, Olivier Azam, Jack Forster, Will James, Alex Brown, Peter Buxton (capt), Andy Hazell, James Forrester. Reps: Mefin Davies, Patrice Collazo, Adam Eustace, Jonathan Pendlebury, Haydn Thomas, Jon Goodridge, Rudi Keil.
Gloucester Rugby gained a third successive victory in the Guinness Premiership with their win over Leicester Tigers at Kingsholm on Sunday. Coral.co.uk, official betting and gaming partner of the Guinness Premiership have priced Gloucester at 1 to 4 favourites to win having only lost one match at Kingsholm this season so confidence will be riding high. Harlequins, the form team in the first 6 weeks of the calendar year have slipped to successive defeats in their previous two matches. However having won three times on the road this season in the Guinness Premiership Coral.co.uk price Quins to win at 5 to 2
Gloucester 1 to 4
Harlequins 5 to 2
Draw 20 to 1
To place a bet on this game please visit www.coral.co.uk/rugby for all the betting odds as well as all other Guinness Premiership and the final round of RBS 6 Nations matches this weekend. Plus open a new account and win a £10 FREE BET and for the month of March Coral.co.uk will double that and provide your favourite Guinness Premiership club with £20 for every account opened.