ENGLAND international Olly Morgan will wear the number 15 shirt for Gloucester's pivotal Heineken Cup match against Bourgoin tomorrow.
Iain Balshaw moves to the wing to cover the absence of Lesley Vainikolo, who has returned to New Zealand for a week because of a family bereavement.
"Our thoughts are with Lesley and his family at this time and the club will give him all the support he needs before he returns to the first team squad," said head coach Dean Ryan.
"Family is very much central to Lesley's life and for that reason we respect his wishes to be with them at this time and want his privacy to be maintained. We will not be making any further comment until he returns."
The rest of Ryan's line-up remains virtually intact from the one that has seen Gloucester establish a narrow lead in Pool Two - although he is without second row Marco Bortolami (calf) and breakaway flanker Andy Hazell (twisted knee).
Mike Tindall and Anthony Allen will resume their centre partnership having missed the EDF Energy Cup victory over the Dragons and James Simpson-Daniel returns to the wing.
Ryan Lamb is partnered by Rory Lawson at half-back.
"We need to combine experience with flair and a cutting edge and we believe this backline provides that," Ryan added. "We are heading for a confrontational environment, an environment in which Bourgoin have a good record and we must be ready to handle that.
"The pool is very much still alive which is why these two back-to-back games are so important. Preparation has been good, we have learnt a great deal over the last year or so in this competition about how to win games like this and we must put that into practice tomorrow."
Ryan's forward pack is also experienced. Nick Wood, who signed a new two-year contract extension last week, starts at loose-head, Olivier Azam at hooker and Carlos Nieto at tight-head.
Peter Buxton will skipper the side from the second row alongside Alex Brown. That allows the tough tackling Alasdair Strokosch to wear number six, Akapusi Qera comes in for Hazell and Gareth Delve, outstanding against the Dragons, wears eight.
"Everyone appreciates the intensity levels of this game and central to that will be the performance of our forwards," Ryan said. "We have stacked up well in this competition and we must maintain that.
"This is a game we are thoroughly looking forward to as a group because of its significance."
Ryan has split his bench four-three in favour of his forwards. Andy Titterrell and Christian Califano will be the front row replacements Will James will cover lock and Luke Narraway the back row.
Scrum-half Gareth Cooper, stand-off Chris Paterson and utility back Leon Lloyd are the three-quarter replacements.
GLOUCESTER (v Bourgoin, tomorrow): Olly Morgan; James Simpson-Daniel, Mike Tindall, Anthony Allen, Iain Balshaw; Ryan Lamb, Rory Lawson; Nick Wood, Olivier Azam, Carlos Nieto, Peter Buxton (capt), Alex Brown, Alasdair Strokosch, Akapusi Qera, Gareth Delve. Reps: Andy Titterrell, Christian Califano, Will James, Luke Narraway, Gareth Cooper, Chris Paterson, Leon Lloyd.
Willi Heinz scored Gloucester's second try as the Cherry and Whites overturned a disappointing first 40 minutes and 0-6 half time deficit, to earn a 26-18 Aviva Premiership victory over Bristol Rugby on Saturday.
It's the first Gloucester-Bristol derby at Kingsholm in over eight years this Saturday (kick off 4:30pm) and, previewing the game with the local media this week, Defence Coach Jonny Bell stressed that, with both teams in the bottom half of the table, they both need the points.
Speaking to the local media this week, Gloucester front rower John Afoa knows the challenge ahead this week against Bristol, and calls on the Cherry and Whites to make the most of home advantage as a determined squad look to bounce back from a narrow loss to Saracens.
Tom Savage speaks to GRTV and the local media as Gloucester went down by 24-20 at Saracens on Sunday afternoon. The second row was disappointed with the result, despite a strong showing from the hosts.
Speaking immediately after the game, skipper Willi Heinz thought that Gloucester had executed their game plan reasonably well and competed hard against Saracens. However, it wasn't enough but the squad will have plenty to work on this week ahead of the derby match against Bristol.
Gloucester may be coming off their best win of the season, the 38-16 victory over Wasps last weekend, but Director of Rugby David Humphreys admits that Sunday's trip to Saracens is an even tougher test.
Looking to try a new sport? Look no further than Walking Rugby as thanks to Gloucester Rugby you can come along and try out the fast-growing sport at taster sessions across the county, starting this Wednesday.
Gloucester return to European Rugby Challenge Cup action on Thursday evening with the visit of Stade Rochelais to Kingsholm (kick off 7:45pm). Early Bird ticket prices are available until 6:30pm on matchday.
Talk about a game of two halves. Things looked grim on Saturday as Gloucester trailed 0-6 to Bristol at half-time. However, Matt Scott's eighth try of the season got Gloucester off and running, and the visitors fell apart as the Cherry and Whites eased to a 26-18 bonus point Aviva Premiership win.