Gloucester Rugby centre Ryan Mills, London Irish wing Jonathan Joseph, Bath Rugby scrum half Chris Cook, Northampton Saints hooker Mike Haywood and Leicester Tigers flanker Matt Everard all come into the starting XV for the Grand Slam deciding fixture.
England are well placed in the group with four wins from four and Head Coach Rob Hunter says that he will have no problem motivating his side as they aim for a first clean sweep since 2008.
He said: "Ireland will be tough, they are the defending champions and they rarely lose in Athlone. We've had an excellent tournament so far and we know what's at stake on Friday night. We'll be focusing purely on performance and matching the challenge that Ireland represent."
England starting XV to face Ireland:
Ben Ransom; Andy Short, Elliot Daly, Ryan Mills, Jonathan Joseph; George Ford, Chris Cook; Mako Vunipola, Mike Haywood, Henry Thomas; Joe Launchbury, Charlie Matthews; Matt Kvesic, Matt Everard, Alex Gray
Rob Buchanan, Will Collier, Addison Lockley, Sam Jones, Dan Robson, Owen Farrell, Jamie Elliott