Uncapped Gloucester prop Nick Wood has been named amongst the replacements for England for Saturday's clash with the Barbarians.
Wood's selection means that he could potentially be lining up against Gloucester team mate Greg Somerville who starts at tight head for the Barbarians.
Lewis Moody is back in the England side after a 15 month absence and six players will make their first starts.
World Cup winner Moody, a Guinness Premiership winner and Heineken Cup finalist with Leicester Tigers this season, hasn't featured for England since the opening game of the 2008 RBS 6 Nations against Wales.
The 30-year-old lines up in the back-row with Nick Easter and uncapped Harlequins flanker Chris Robshaw, the Guinness Premiership's Player of the Season.
The five other players making their first start are Dylan Hartley and Ben Foden, who were European Challenge Cup winners with Northampton Saints last week, and Harlequins centre Jordan Turner-Hall, Bath Rugby wing Matt Banahan and Newcastle Falcons prop David Wilson.
England team manager Martin Johnson also calls on captain Steve Borthwick (Saracens) and Delon Armitage (London Irish), who played throughout the 2009 RBS 6 Nations campaign, while hooker Steve Thompson and flanker James Haskell are among the replacements.
The game will be England's final appearance of the 2008/09 season at Twickenham before they prepare for their two Test series against Argentina at Old Trafford on June 6 and Salta, Argentina, on June 13.
Delon Armitage (London Irish); Ben Foden (Northampton Saints), Jamie Noon (Newcastle Falcons), Jordan Turner-Hall (Harlequins)*, Matt Banahan (Bath Rugby)*; Andy Goode (CA Brive), Danny Care (Harlequins); Tim Payne (London Wasps), Dylan Hartley (Northampton Saints), David Wilson (Newcastle Falcons)*; Steve Borthwick (Saracens, captain), Louis Deacon (Leicester Tigers); Chris Robshaw (Harlequins)*, Lewis Moody (Leicester Tigers)
8 Nick Easter (Harlequins)
Steve Thompson (CA Brive), Nick Wood (Gloucester Rugby)*, Chris Jones (Sale Sharks), Steffon Armitage (London Irish), James Haskell (London Wasps), Paul Hodgson (London Irish), Tom May (Newcastle Falcons)*
* Uncapped players (note that this is not a Test match and caps are not awarded for this game).
Henry Purdy, a first half replacement for Charlie Sharples, was amongst the try scorers in the 64-19 victory over Aviron Bayonnais on Saturday evening and told GRTV that it was a professional performance, one the team are happy with.
Gloucester's win in Treviso last week means that they need a bonus point win against Bayonne on Saturday evening to secure a home quarter-final (kick off 8pm), but Tim Taylor wants the team to focus on the performance first and foremost.
Billy Burns and Man of the Match Richard Hibbard spoke to GRTV after the 41-0 win in Treviso, on a day when preparations weren't ideal. They felt the team's attitude was key and also praised the travelling support.
Matt Scott was again in impressive try scoring form for the Cherry and Whites on Saturday, and the Scotsman laid praise on his fellow backs for their attacking skills in a big 55-19 win over Worcester Warriors
Knowing a bonus point win would secure a home quarter-final, Gloucester completed their European mission in some style on Saturday evening, sweeping aside a spirited but outgunned Aviron Bayonnais scoring 10 tries on their way to a 64-19 victory.
The Gloucester Rugby Heroes are back this month, and the huge array of past stars of Cherry and White, with a sprinkling of sporting legends and TV stars will assemble to take on the South African Legends on Sunday 29th January at Kingsholm.