Uncapped Gloucester prop Nick Wood has been named amongst the replacements for England for Saturday's clash with the Barbarians.
Wood's selection means that he could potentially be lining up against Gloucester team mate Greg Somerville who starts at tight head for the Barbarians.
Lewis Moody is back in the England side after a 15 month absence and six players will make their first starts.
World Cup winner Moody, a Guinness Premiership winner and Heineken Cup finalist with Leicester Tigers this season, hasn't featured for England since the opening game of the 2008 RBS 6 Nations against Wales.
The 30-year-old lines up in the back-row with Nick Easter and uncapped Harlequins flanker Chris Robshaw, the Guinness Premiership's Player of the Season.
The five other players making their first start are Dylan Hartley and Ben Foden, who were European Challenge Cup winners with Northampton Saints last week, and Harlequins centre Jordan Turner-Hall, Bath Rugby wing Matt Banahan and Newcastle Falcons prop David Wilson.
England team manager Martin Johnson also calls on captain Steve Borthwick (Saracens) and Delon Armitage (London Irish), who played throughout the 2009 RBS 6 Nations campaign, while hooker Steve Thompson and flanker James Haskell are among the replacements.
The game will be England's final appearance of the 2008/09 season at Twickenham before they prepare for their two Test series against Argentina at Old Trafford on June 6 and Salta, Argentina, on June 13.
Delon Armitage (London Irish); Ben Foden (Northampton Saints), Jamie Noon (Newcastle Falcons), Jordan Turner-Hall (Harlequins)*, Matt Banahan (Bath Rugby)*; Andy Goode (CA Brive), Danny Care (Harlequins); Tim Payne (London Wasps), Dylan Hartley (Northampton Saints), David Wilson (Newcastle Falcons)*; Steve Borthwick (Saracens, captain), Louis Deacon (Leicester Tigers); Chris Robshaw (Harlequins)*, Lewis Moody (Leicester Tigers)
8 Nick Easter (Harlequins)
Steve Thompson (CA Brive), Nick Wood (Gloucester Rugby)*, Chris Jones (Sale Sharks), Steffon Armitage (London Irish), James Haskell (London Wasps), Paul Hodgson (London Irish), Tom May (Newcastle Falcons)*
* Uncapped players (note that this is not a Test match and caps are not awarded for this game).
Motu Matu'u is looking to make up for lost time this week as the Cherry and Whites head to Basque Country to take on Bayonne in the European Rugby Challenge Cup opener. The Samoan hooker made his first appearance in the jersey last weekend, and is hoping to contribute to the team this weekend.
Gloucester's attentions turn to Europe this weekend as they travel to Bayonne for their opening fixture of this season's European Rugby Challenge Cup. Forwards Coach Trevor Woodman told GRTV that the Cherry and Whites will be aiming to top their pool as they've done for the past two seasons, but is well aware of how tough it is to win in France.
Although understandably disappointed at seeing victory slip away at the last minute, Ben Morgan said after the game at Exeter that there were plenty of positives that Gloucester could take from the game.
Speaking after a last-gasp try from Exeter earned the Chiefs a 27-27 draw at Sandy Park on Saturday, Charlie Sharples admitted to mixed feelings. The game saw him score a try on his 200th competitive appearance for the club, but the frustration from not closing out the win was clear.
David Humphreys was minutes away from a winning interview on Saturday afternoon, but a late try from Exeter Chiefs meant the points were shared at Sandy Park. Humphreys spoke with the local media after the 27-27 draw.
Speaking to the media ahead of Saturday's Aviva Premiership fixture away at Exeter Chiefs, Director of Rugby David Humphreys reiterated that there are elements of Gloucester's game that are in good shape at present, that the performance against Bath was a step forward from Newcastle but that individual errors are costing the Cherry and Whites dear.
Lesley Vainikolo was a welcome visitor to Kingsholm this week, reminiscing as he wandered around the stadium. The big winger is back in Gloucester to take part in Sunday's Mitsubishi Motors UK Hybrid Cup (kick off 3pm).
Centre Matt Scott, a try-scorer in Bayonne last weekend, insists that Gloucester are taking nothing for granted when they welcome Benetton Treviso to Kingsholm on Saturday in the European Rugby Challenge Cup (kick off 3pm).