Uncapped Gloucester prop Nick Wood has been named amongst the replacements for England for Saturday's clash with the Barbarians.
Wood's selection means that he could potentially be lining up against Gloucester team mate Greg Somerville who starts at tight head for the Barbarians.
Lewis Moody is back in the England side after a 15 month absence and six players will make their first starts.
World Cup winner Moody, a Guinness Premiership winner and Heineken Cup finalist with Leicester Tigers this season, hasn't featured for England since the opening game of the 2008 RBS 6 Nations against Wales.
The 30-year-old lines up in the back-row with Nick Easter and uncapped Harlequins flanker Chris Robshaw, the Guinness Premiership's Player of the Season.
The five other players making their first start are Dylan Hartley and Ben Foden, who were European Challenge Cup winners with Northampton Saints last week, and Harlequins centre Jordan Turner-Hall, Bath Rugby wing Matt Banahan and Newcastle Falcons prop David Wilson.
England team manager Martin Johnson also calls on captain Steve Borthwick (Saracens) and Delon Armitage (London Irish), who played throughout the 2009 RBS 6 Nations campaign, while hooker Steve Thompson and flanker James Haskell are among the replacements.
The game will be England's final appearance of the 2008/09 season at Twickenham before they prepare for their two Test series against Argentina at Old Trafford on June 6 and Salta, Argentina, on June 13.
Delon Armitage (London Irish); Ben Foden (Northampton Saints), Jamie Noon (Newcastle Falcons), Jordan Turner-Hall (Harlequins)*, Matt Banahan (Bath Rugby)*; Andy Goode (CA Brive), Danny Care (Harlequins); Tim Payne (London Wasps), Dylan Hartley (Northampton Saints), David Wilson (Newcastle Falcons)*; Steve Borthwick (Saracens, captain), Louis Deacon (Leicester Tigers); Chris Robshaw (Harlequins)*, Lewis Moody (Leicester Tigers)
8 Nick Easter (Harlequins)
Steve Thompson (CA Brive), Nick Wood (Gloucester Rugby)*, Chris Jones (Sale Sharks), Steffon Armitage (London Irish), James Haskell (London Wasps), Paul Hodgson (London Irish), Tom May (Newcastle Falcons)*
* Uncapped players (note that this is not a Test match and caps are not awarded for this game).
Speaking to GRTV after the 33-19 win over Glasgow Warriors on Friday night, Laurie Fisher was delighted to get the win and a stern defensive examination in the final run out before the start of the new domestic season.
Speaking at the launch of the Aviva Premiership at Twickenham on Thursday, Gloucester Rugby skipper Greig Laidlaw spoke about the team's preparations and how they're all eagerly awaiting the big kick-off against Leicester.
Matt Scott made his first appearance in Cherry and White on Saturday afternoon, and despite a narrow loss to Leinster, the Scotsman highlighted a lot to be pleased about after the first hit out of the new season.
Lloyd Evans will assume a senior role in the Gloucester Rugby squad as they head to Franklin's Gardens for the Singha Premiership Rugby 7s on Friday evening. The exciting Academy fly half spoke to GRTV this week ahead of the season curtain-raiser.
Summer signing Matt Scott met with the local media for the first time this week and said that he's settling in well at Gloucester, that hopes are high for the forthcoming season and that skipper Greig Laidlaw had done a good sales pitch when it came to him signing!
Olly Morgan is heading up Gloucester's Singha Premiership 7s once again this summer and, with the start of the tournament just around the corner, he's looking for some of the club's younger players to make the most of the playing time and the exposure it offers.
The Cherry & Whites are now in their second full week of preseason ahead of the new season, and GRTV caught up with the new Head of Strength & Conditioning Dan Tobin to chat about what is in store, and his first impressions of the club.
Premiership Rugby can today confirm that Newcastle Falcons' trip to Franklin's Gardens kicks off the next set of matches live on BT Sport, with Gloucester's trip to Saracens in round nine also affected.
Gloucester Rugby's inaugural Beach Weekender last August Bank Holiday was a phenomenal success. This year's event has surpassed it with thousands taking part at Gloucester Quays over the past three days.
If Gloucester were looking for a defensive workout, they certainly got it in the first half. But they cut loose in the second to run out winners by 33 points to 19 to finish preseason on a positive note.