Uncapped Gloucester prop Nick Wood has been named amongst the replacements for England for Saturday's clash with the Barbarians.
Wood's selection means that he could potentially be lining up against Gloucester team mate Greg Somerville who starts at tight head for the Barbarians.
Lewis Moody is back in the England side after a 15 month absence and six players will make their first starts.
World Cup winner Moody, a Guinness Premiership winner and Heineken Cup finalist with Leicester Tigers this season, hasn't featured for England since the opening game of the 2008 RBS 6 Nations against Wales.
The 30-year-old lines up in the back-row with Nick Easter and uncapped Harlequins flanker Chris Robshaw, the Guinness Premiership's Player of the Season.
The five other players making their first start are Dylan Hartley and Ben Foden, who were European Challenge Cup winners with Northampton Saints last week, and Harlequins centre Jordan Turner-Hall, Bath Rugby wing Matt Banahan and Newcastle Falcons prop David Wilson.
England team manager Martin Johnson also calls on captain Steve Borthwick (Saracens) and Delon Armitage (London Irish), who played throughout the 2009 RBS 6 Nations campaign, while hooker Steve Thompson and flanker James Haskell are among the replacements.
The game will be England's final appearance of the 2008/09 season at Twickenham before they prepare for their two Test series against Argentina at Old Trafford on June 6 and Salta, Argentina, on June 13.
Delon Armitage (London Irish); Ben Foden (Northampton Saints), Jamie Noon (Newcastle Falcons), Jordan Turner-Hall (Harlequins)*, Matt Banahan (Bath Rugby)*; Andy Goode (CA Brive), Danny Care (Harlequins); Tim Payne (London Wasps), Dylan Hartley (Northampton Saints), David Wilson (Newcastle Falcons)*; Steve Borthwick (Saracens, captain), Louis Deacon (Leicester Tigers); Chris Robshaw (Harlequins)*, Lewis Moody (Leicester Tigers)
8 Nick Easter (Harlequins)
Steve Thompson (CA Brive), Nick Wood (Gloucester Rugby)*, Chris Jones (Sale Sharks), Steffon Armitage (London Irish), James Haskell (London Wasps), Paul Hodgson (London Irish), Tom May (Newcastle Falcons)*
* Uncapped players (note that this is not a Test match and caps are not awarded for this game).
Speaking to GRTV this week, Director of Rugby David Humphreys reflected on last week's win in La Rochelle as well as an A League semi-final triumph, but insisted that focus has quickly switched to Sunday's crucial Aviva Premiership fixture at Bath.
Speaking to GRTV after the 40-29 Aviva A League win over Wasps Rugby, Academy Coach Rich Whiffin explained his pride in the squad to overcome a strong opponent and book their spot in next week's Aviva A League final.
Willi Heinz returned from injury to skipper Gloucester to a famous 16-14 win over Stade Rochelais on Saturday evening. Speaking after the game in France, Heinz admitted the win wasn't pretty but was full of courage and a great result for the club.
Billy Burns contributed all Gloucester's points in the 16-14 European Rugby Challenge Cup win in La Rochelle on Saturday evening, but dedicated the victory to the whole squad whilst also praising the travelling support.
Speaking after Gloucester's brave 16-14 win against Stade Rochelais which clinches a European Rugby Challenge Cup final spot, Director of Rugby David Humphreys paid tribute to the way the team had executed the game plan in a hostile environment against quality opposition.
Greig Laidlaw returns to the Gloucester Rugby squad this week, and his inclusion is an important one after a serious ankle injury. The Scottish scrum half is determined to drive the team forward in their European Rugby Challenge Cup semi final in La Rochelle this Saturday.
Gloucester take on La Rochelle in the European Rugby Challenge Cup semi-final in France on Saturday evening, with the Top 14 side the favourites in the eyes of the bookmakers. However, David Humphreys is looking for his side to rise to the occasion against a familiar opponent.
Local junior rugby teams had the honour of trotting out onto the Kingsholm pitch on Saturday morning, with over 400 young players representing their local clubs in the finals of the Wooden Spoon Charity Floodlit Tournament.