O'Driscoll skippers a side which features several players the local supporters will be pleased to see as Mike Tindall and Rory Lawson both start with Akapusi Qera named amongst the replacements.
Tindall will partner Damien Traille in a powerful midfield combination while Lawson links up at half back with Felipe Contepomi, who lines up not far from his old stamping ground at Bristol.
Also, coming into the starting line up as well as the above after the defeat by England on Sunday are Cedric Heymans, Sailosi Tagicakibau, Duncan Jones, Benoit August, Cornelius Van Zyl and a completely new back row of Mamuka Gorgodze, Francois Louw, Raphael Lakafia.
Cedric Heymans; Paul Sackey, Mike Tindall, Damien Traille, Sailosi Tagicakibau; Felipe Contepomi, Rory Lawson; Duncan Jones, Benoit August, John Afoa; Mick O'Driscoll (capt), Cornelius Van Zyl; Mamuka Gorgodze, Francois Louw, Raphael Lakafia
Aled de Malmanche, Neemia Tialata, Pelu Taele, Akapusi Qera, Richie Rees, Stephen Donald, Isa Nacewa