Teenage full-back Stuart Hogg will make his first Scotland start as Andy Robinson makes four changes to his side.
The 19-year-old, who was replacement against Wales, is named along with Glasgow Warriors team-mates Graeme Morrison and John Barclay.
Mike Blair is preferred to British and Irish Lions team-mate Chris Cusiter at scrum-half. Gloucester's Rory Lawson misses out.
Meanwhile, Blair's Edinburgh team-mate, Greig Laidlaw, retains his place at fly-half.
Stuart Hogg; Rory Lamont, Lee Jones, Sean Lamont, Graeme Morrison; Greig Laidlaw, Mike Blair; Allan Jacobsen, Ross Ford (captain), Geoff Cross; Richie Gray, Jim Hamilton; John Barclay, Ross Rennie, David Denton.
Scott Lawson, Ed Kalman, Alastair Kellock, Richie Vernon, Chris Cusiter, Duncan Weir, Nick De Luca.