However, a first half injury to Ugo Monye saw May get his opportunity and Gloucester's Young Player of the Season didn't waste it.
A startling burst of pace and eye for an opening saw him make good ground before chipping ahead for Nick Abendanon to complete a first half hat trick.
However, he came into his own after the break as the game opened up.
His first try was brilliantly taken as he gathered in a pass that was half a yard behind him before breaking one tackle and then pirouetting out of another to finish superbly.
He then embarked upon a superb arcing run, reminiscent of his try against Harlequins last season, and was only hauled down just short of the line.
His contribution was completed as he took George Robson's inside offload to stretch for the line for his second.
England ran out fairly comfortable 57-31 winners, a win which was virtually secured in the first half although a good 20 minutes after the interval saw the home side turn a 31-10 half time deficit into a 31-24 contest.
Gloucester bound number eight Ben Morgan scored from close range in the first half to add to Abendanon's triple.
Anthony Allen crossed late on before the England scrum, by now featuring Rupert Harden in the front row, finished things off with a penalty try.