Glasgow Warriors stand off Duncan Weir will make his first start of the RBS Six Nations, while Euan Murray returns at tight head having sat out the Ireland game due to religious reasons.
Former Gloucester flanker Alasdair Strokosch, who suffered a bad facial injury in the tournament opener against England, has returned to the squad but not made the matchday 23.
Scotland interim Head Coach Scott Johnson is under no illusions about the size of the task in hand:
"This is another step up - they're a quality side and current champions and probably the form side over the last four or five years in the north.
"There's no excuses. It's a good test for us and it'll show us where we are and test our character. But I've no doubt there is good enough character in our side to make it competitive."
Stuart Hogg, Sean Maitland, Sean Lamont, Matt Scott, Tim Visser, Duncan Weir, Greig Laidlaw; Ryan Grant, Ross Ford, Euan Murray, Richie Gray, Jim Hamilton, Robert Harley, Kelly Brown, Johnnie Beattie
Dougie Hall, Moray Low, Geoff Cross, Alastair Kellock, Ryan Wilson, Henry Pyrgos, Ruaridh Jackson, Max Evans