Hooker Cameron Neild scored England's first try, with fly half Sam Olver adding the conversion, followed shortly afterwards by a penalty to take England 10-0 ahead.
Wales fought back with a sustained spell of pressure but were unable to convert this into points. Two tries quickly followed from scrum half Stuart Townsend wing Nathan Earle to extend the visitors lead to 24-0.
England had their fourth try just before the break. After a scrum five yards out, the impressive Townsend picked up the ball to dot down for his second try, his fourth try in a week after scoring twice against Scotland last weekend.
With 40 minutes played, lock Ewels gained possession and ran the ball in from the half way line and, ten minutes later England had their sixth, electric wing Zach Kibirige scoring.
Hosts Wales got onto the scoreboard in the 65th minute when Steff Evans touched down and Luke Price converted, but it was to be England who had the final say as Earle ran in to score his second try to secure the 44-7 win.