After leading the Sevens side, Martyn Thomas starts at full back, while Ryan Mills and Jimmy Cowan, who both returned from injury against Munster, are again named at centre and scrum-half respectively.
There will be a first Kingsholm appearance for fly-half Jonny Bentley, Drew Cheshire on the wing and Dan George at hooker.
Academy players Tom Hicks, Lewis Ludlow and Reece Boughton are named amongst the replacements, along with trialist Jaryd Robinson who impressed the Kingsholm coaches whilst playing for the New York City 7s side in this month's World Club Sevens, which included a hat-trick against the Cherry and Whites.
Meanwhile, Director of Rugby Nigel Davies has named a strong side as Gloucester take on his old club, the Scarlets, in the evening's second fixture.
Tom Savage captains the side for the first time since being announced as Gloucester Rugby captain.
There will also be first Kingsholm appearances for summer signings Matt Kvesic, James Hudson and Tavis Knoyle.
There is also a welcome return to the Kingsholm turf for winger James Simpson-Daniel, and British and Irish Lion Billy Twelvetrees starts at centre hoping to reignite the partnership he struck up with Freddie Burns for club and country last season
Gloucester Rugby vs Plymouth Albion:
Martyn Thomas; Steph Reynolds, Tim Molenaar, Ryan Mills, Drew Cheshire; Jonny Bentley, Jimmy Cowan; Dan Murphy, Dan George, Tom Heard; Elliott Stooke, Will James; Matt Cox, Andy Hazell (capt), Gareth Evans.
Koree Britton, James Gibbons, Yann Thomas, Tom Hicks, Lewis Ludlow, Reece Boughton, Billy Burns, Mike Tindall, Jaryd Robinson, Will Hayward.
Gloucester Rugby vs Scarlets:
Rob Cook; Charlie Sharples, Henry Trinder, Billy Twelvetrees, James Simpson-Daniel; Freddie Burns, Tavis Knoyle; Nick Wood, Darren Dawidiuk, Rupert Harden; Tom Savage (capt), James Hudson; Sione Kalamafoni, Matt Kvesic, Ben Morgan.
Koree Britton, Dan Murphy, Yann Thomas, Lua Lokotui, Akapusi Qera, Dan Robson, Billy Burns, Mike Tindall, Steph Reynolds.