Joe Marler, Dylan Hartley and David Wilson replace Mako Vunipola, Tom Youngs and Dan Cole against the Pumas.
Cole and Youngs are included on an experienced replacements' bench, which also sees the return from concussion and injury of fellow British & Irish Lions Alex Corbisiero and Geoff Parling.
England Head Coach Stuart Lancaster said: "Joe Marler was excellent off the bench against Australia and merits his opportunity, as does David Wilson, who has been pushing hard for selection.
"Dylan gets a deserved chance at hooker with Tom Youngs on the bench after the safe arrival of his first child this morning. Rob Webber remains on standby.
"Christian Wade was in contention for a start but his hamstring tightened up in training and unfortunately he hasn't recovered sufficiently in time to be considered for Saturday. Marland Yarde failed a fitness test on a hip injury sustained last weekend this morning so Ben Foden gets his chance with Alex Goode on the bench. Ben has had a full week's training on the wing, he is a great finisher and in form so it's a great option for us.
"The Twickenham crowd was superb against Australia and we were pleased to get the victory but we know there's more to come from this team and we are looking forward to building on that momentum for this weekend."
England (v Argentina, QBE International, Saturday, 2.30pm, Twickenham Stadium, live on Sky Sports 2 HD & 3D)
15 Mike Brown (Harlequins, 19 caps) 14 Chris Ashton (Saracens, 35 caps) 13 Joel Tomkins (Saracens, 1 cap) 12 Billy Twelvetrees (Gloucester Rugby, 6 caps) 11 Ben Foden (Northampton Saints, 32 caps) 10 Owen Farrell (Saracens, 17 caps) 9 Lee Dickson (Northampton Saints, 10 caps) 1 Joe Marler (Harlequins, 13 caps) 2 Dylan Hartley (Northampton Saints, 48 caps) 3 David Wilson (Bath Rugby, 29 caps) 4 Joe Launchbury (London Wasps, 12 caps) 5 Courtney Lawes (Northampton Saints, 23 caps) 6 Tom Wood (Northampton Saints, 21 caps) 7 Chris Robshaw (Harlequins, capt, 18 caps) 8 Billy Vunipola (Saracens, 3 caps)
16 Tom Youngs (Leicester Tigers, 10 caps) 17 Alex Corbisiero (Northampton Saints, 18 caps) 18 Dan Cole (Leicester Tigers, 41 caps) 19 Geoff Parling (Leicester Tigers, 17 caps) 20 Ben Morgan (Gloucester Rugby, 13 caps) 21 Ben Youngs (Leicester Tigers, 34 caps) 22 Toby Flood (Leicester Tigers, 58 caps) 23 Alex Goode (Saracens, 11 caps)