The only other change sees Leicester Tigers flanker Will Owen come in for Exeter's Joel Conlon while Leicester prop Harry Rudkin and Exeter No. 9 Stuart Townsend come onto the replacements bench.
After the 21-15 defeat against France in their opening game, Head Coach Nick Walshe says that he's looking for a reaction from his players.
"It was frustrating against France because we know that we could have caused them a few more problems, but it just wasn't to be in that game. We've got faith in the back-line to deliver this week and hopefully the forwards can create a platform and we can go out there and perform like I know we can."
On the introduction of Walker, he added:
"He's a really talented player. It was a shame to lose Harry [Thacker], but he's gone back to Leicester which is great for him, and it gives us a chance to give Jack a game which is something we had planned to do later in the tournament anyway.
"But Jack is a very good player and I'm sure he'll stand up to the Scottish challenge."
Tune in to watch Scotland Under 20s against England live on RFU.com, with coverage starting at 7.30pm.
England Under 20s starting XV against Scotland
15 Nathan Earle (Saracens)
14 Zach Kibirige (Newcastle Falcons)
13 Nick Tompkins (Saracens)
12 Tom Stephenson (Northampton Saints)
11 Henry Purdy (Leicester Tigers)
10 Billy Burns (Gloucester Rugby)
9 Callum Braley (Bristol Rugby, captain)
1 Danny Hobbs-Awoyemi (Northampton Saints)
2 Jack Walker (Leeds Carnegie)
3 Paul Hill (Leeds Carnegie)
4 Maro Itoje (Saracens)
5 Charlie Ewels (Bath Rugby)
6 Ross Moriarty (Gloucester Rugby)
7 Will Owen (Leicester Tigers)
8 James Chisholm (Harlequins)
16 Tom Woolstencroft (Bath Rugby)
17 Alex Lundberg (London Wasps)
18 Harry Rudkin (Leicester Tigers)
19 Tom Ellis (Bath Rugby)
20 Joel Conlon (Exeter Chiefs)
21 Stuart Townsend (Exeter Chiefs)
22 Sam Olver (Northampton Saints)
23 Howard Packman (Northampton Saints)