England Head Coach Stuart Lancaster said:
"We feel that the time is right to include George Ford in the matchday squad. A full three weeks of training has allowed him the chance to really understand the way we are developing our game and this time has been crucial in order for him to feel confident and ready in a key decision making and leadership position.
"We have successfully integrated and included many young players over the last two years and George is the next exciting talent to make his mark in the senior squad and we are a looking forward to see him develop over the next few months.
"Brad Barritt is obviously disappointed to miss out but he is still a key member of our squad and I am sure he will get further opportunities in the future. He hasn't had much game time since his injury and will benefit from some time with Saracens over the next two weeks."
Dan Cole saw a specialist this evening regarding his neck and the results of the assessment will now be considered by the England and Leicester Tigers medical teams.
David Attwood (Bath Rugby), Dylan Hartley (Northampton Saints), Joe Launchbury (London Wasps), Courtney Lawes (Northampton Saints), Joe Marler (Harlequins), Ben Morgan (Gloucester Rugby), Chris Robshaw (Harlequins), Henry Thomas (Sale Sharks), Billy Vunipola (Saracens), Mako Vunipola (Saracens), David Wilson (Bath Rugby), Tom Wood (Northampton Saints), Tom Youngs (Leicester Tigers)
Mike Brown (Harlequins), Luther Burrell (Northampton Saints), Danny Care (Harlequins), Lee Dickson (Northampton Saints), Owen Farrell (Saracens), George Ford (Bath Rugby), Alex Goode (Saracens), Jonny May (Gloucester Rugby), Jack Nowell (Exeter Chiefs), Billy Twelvetrees (Gloucester Rugby)
Meanwhile, the following players will return to their clubs:
Chris Ashton (Saracens), Brad Barritt (Saracens, Freddie Burns (Gloucester Rugby), Kyle Eastmond (Bath Rugby), Matt Kvesic (Gloucester Rugby), Tom Johnson (Exeter Chiefs), Matt Mullan (London Wasps), Ed Slater (Leicester Tigers), Anthony Watson (Bath Rugby), Ben Youngs (Leicester Tigers)