Stuart Lancaster's side had a dream start thanks to Danny Care's opportunist try after a quick tap penalty and were never pegged back.
The only real threat from a strangely lacklustre Wales was from the boot of Leigh Halfpenny. The full back kicked five penalties in the first half but only one after the interval.
Billy Twelvetrees was the architect of England's second try, his measured grubber kick standing up perfectly for Luther Burrell. It was the highlight of a composed display in which he barely put a foot wrong.
Ben Morgan made the most of his recall, carrying with purpose and putting in a big shift defensively.
Jonny May rarely got the ball in space, but looked sharp when he did receive possession. And he did a good job in defence on Alex Cuthbert.
A good day at the office for England and Gloucester.